Dopamine does not work to treat depression. Dopamine is a neurotransmitter that can affect a person’s mood, for example, dopamine is produced when a person is running, which can cause feelings of excitement and pleasure. However, the direct application of dopamine for depression is not clinically studied. Because the treatment of depression is mainly the application of antidepressants, such as tricyclic and tetracyclic antidepressants, as well as the most used selective 5-hydroxytryptamine reuptake inhibitors, these drugs can increase the secretion of 5-hydroxytryptamine, norepinephrine, and dopamine and other neurotransmitters, thereby regulating depression, anxiety and other adverse moods. However, direct application of dopamine for depression is not effective and may cause other toxic side effects, such as high blood pressure or rapid heart rate.