Constipation is a common and complex clinical symptom, mainly referring to the decrease in the number of bowel movements, the decrease in the volume of stool, the dryness of stool, and the effort to defecate. It must be determined by taking into account the nature of the stool, the person’s usual bowel habits and the difficulty in defecating. Once it is confirmed that you are suffering from constipation, if diet and simple dietary therapy do not help, you need to use safe, effective and long-term medication for conservative treatment. Currently, the following types of laxatives are commonly used in clinical practice: 1, volumetric laxatives (bulking drugs) by retaining water in the stool, increasing the water content of stool and stool volume to play a laxative effect, mainly for patients with mild constipation, remember to supplement water before taking the drug. At present, the commonly used drugs are Ou Che Qian, polycarbophil calcium, wheat bran, etc. 2, osmotic laxatives can form a hypertonic state in the intestine, absorb water, increase the volume of stool, stimulate intestinal peristalsis, can be used for patients with mild to moderate constipation. Drugs include polyethylene glycol, non-absorbed sugars (such as lactulose) and salt laxatives (such as magnesium sulfate). It is necessary to explain that the excessive application of salt laxatives may cause electrolyte disorders, the elderly and renal decompensation should be used with caution. 3, stimulating laxatives This type of drug mainly acts on the enteric nervous system, by enhancing intestinal dynamics and stimulating intestinal secretion to relieve constipation symptoms. Mainly including Bisacodyl, phenolphthalein, anthraquinone drugs and castor oil, etc.. All these drugs are recommended for short-term use only. It is also worth stating that phenolphthalein has been withdrawn from the market due to its possible carcinogenic effects found in animal experiments. There are also rhubarb, cassia, aloe vera, senna and proprietary Chinese medicines containing the ingredients of these drugs. Stimulant laxatives are not suitable for long-term use because they can produce serious toxic side effects. Common toxic side effects are laxative colonization or drug dependence. Some experiments have shown that long-term consumption of stimulant laxatives may lead to irreversible intestinal nerve damage, and long-term use of anthraquinone-based laxatives can lead to colonic melanosis. Therefore, short-term, intermittent use of stimulant laxatives is recommended. 4, prokinetic drugs This drug mainly acts on the intestinal nerve endings, releasing motor neurotransmitters, antagonizing inhibitory neurotransmitters or acting directly on smooth muscle to increase intestinal power, which has a better effect on slow transmission constipation of the colon. Some studies have shown that the promoter Prilucapride can shorten the colon transmission time, and it is safer and better tolerated. 5.Pro-secretory drugs Stimulate the secretion of intestinal fluid and promote defecation, including lubiprostone and linaclotide. Enemas and suppositories are administered intra-anally to lubricate and stimulate the intestinal wall, softening the stool and making it easy to pass. Cecelia belongs to this category, and is suitable for temporary use in patients with dry stools and fecal impaction. 7, proprietary Chinese medicine Qirong Run Intestinal Oral Liquid is a representative of proprietary Chinese medicine for the treatment of constipation, suitable for spleen and kidney Yang deficiency type constipation. It is necessary to note that, now on the market to prevent and control constipation of a wide range of drugs, many have serious toxic side effects, improper use will have serious adverse consequences, for safety reasons, constipation requires drug treatment, should be used under the guidance of a specialist in order to be safe and effective.