To a comprehensive, objective and correct understanding of the gamma knife, should be from the following aspects: (1) Gamma knife is the crystallization of modern high technology, which integrates stereotactic technology, radiation medicine, neurosurgery, modern medical imaging and electronic computer technology in one, is a system engineering. The invention of the gamma knife and good therapeutic effects make directional radiosurgery from concept to reality, directional radiosurgery has now become an important subdiscipline. (2) good instruments and equipment also need people to operate and use, the user factor is always the first. Only the user has more comprehensive knowledge, rich clinical experience, skilled operation and mastery of skills, combined with advanced equipment is possible to obtain good results and reduce the occurrence of side effects. (3) cranial gamma knife can not completely replace craniotomy. Gamma knife treatment has its range of indications, not all cranial diseases are suitable for treatment. At present, for most cranial organic brain diseases, craniotomy is still the basis, is still the first choice. Cranial Gamma Knife as a neurosurgical treatment of many means of treatment, it is not an exclusive relationship with other treatment methods, especially craniotomy, in many cases often need the cooperation of craniotomy. Cranial gamma knife and other neurosurgical treatment methods selectively cooperate with each other, can greatly improve the overall effectiveness of the disease, reduce the patient’s disability rate and mortality. (4) Gamma knife treatment after the target area tissue radiobiological effect can last for 2 to 3 years or even longer, except for a very few diseases with relatively fast effect (metastases, germ cell tumors, etc.), most of the remaining diseases are relatively slow to produce the effect. Gamma knife treatment takes only a few hours from start to finish, and the actual treatment of the lesion takes only about an hour, and most patients can be discharged the day after treatment. The patient’s healing, observation, and recovery periods are mainly spent at home. In other words, after the implementation of gamma knife treatment according to the treatment plan, the lesion tissue gradually produces a series of radiobiological effects in the next few years before gradually producing results. This is where cranial gamma knife treatment is completely different from open-heart surgery. Because of this, it is necessary for patients to closely observe the changes in their condition for at least the next three years after receiving Gamma Knife treatment, to regularly visit the hospital to review the changes in the disease, and to patiently wait for the therapeutic effect. Based on the characteristics of the generation of curative effect after gamma knife treatment and the depth of understanding, the author believes that there is a more appropriate understanding of the regression of the disease treated by gamma knife, that is: “the end of gamma knife treatment is not the end of disease treatment, but the beginning of disease treatment.” With this basic understanding, many clinical problems can be solved, including the choice of indications, communication with patients and their families, and the observation of efficacy. (5) Must be divided into two views to understand the gamma knife. On the one hand, we must recognize the superiority of gamma knife treatment, on the other hand, we must also see its shortcomings. Gamma knife is not a panacea, with a strict range of indications, it is not possible to solve all clinical problems. In the treatment of disease, there is also the possibility of some side effects or complications. We must be divided into two, realistic and scientific point of view to a comprehensive understanding and view of the gamma knife. Only in this way can the gamma knife directed radiosurgery along a healthy track forward. (6) cranial gamma knife is only the most representative gold standard equipment for directional radiosurgery at this stage, will not and cannot be the apex of radiosurgery technology, which can be clearly seen from the history of the development of the gamma knife. As clinical staff, we are eager for more scientific, advanced, efficient and safe treatment methods to emerge, with a view to bringing revolutionary gospel for the majority of patients with cranio-cerebral diseases.