These factors, such as heavy drinking, excessive exercise and drugs, can induce sudden attacks of gout, and one should be particularly alert to these drug factors in the treatment of gout patients. 1, diuretics Diuretics such as furosemide and hydrochlorothiazide, as well as antihypertensive drugs containing diuretics, such drugs can reduce the kidney’s ability to excrete uric acid, causing an increase in uric acid, which can cause or induce gout. 2, antipyretic and analgesic drugs Aspirin has a dual effect on uric acid metabolism. High-dose aspirin (>3 g/d) can significantly inhibit the reabsorption of uric acid by renal tubules, resulting in increased uric acid excretion; medium-dose aspirin (1 – 2 g/d) mainly inhibits uric acid excretion by renal tubules; although there are not many studies on the effect of small-dose aspirin (<0.5 g/d) on uric acid, clinical studies have found that 75 - 325 mg/d dosage of aspirin can impair renal function and uric acid clearance in the elderly. Small doses of aspirin have been widely used in cardiovascular patients, especially in the elderly. Therefore, one should be alert to the damage caused by dose changes in the elderly. Aspirin should be avoided during acute attacks of gout. 3.Antibacterial drugs Most antibiotics such as quinolones (e.g., ofloxacin, gatifloxacin, etc.) and penicillin are excreted by the kidneys, but the excretion of antibiotics such as quinolones and penicillin will affect the excretion of uric acid and increase the level of uric acid in the body. 4, lipid-lowering drugs Niacin is a commonly used drug in lipid-lowering drugs, it has a good lipid-lowering effect, but it also has the obvious side effect of raising blood uric acid. 5.Immunosuppressants Typical drug is cyclosporine, which will reduce the excretion of uric acid. Some rheumatology patients, as well as patients who received organ transplants and take cyclosporine are also at high risk of gout, especially patients with renal insufficiency who have had their hearts or kidneys replaced are less likely to control uric acid. 6, some of the antihypertensive drugs beta-blockers such as metoprolol, calcium antagonists such as nifedipine, amlodipine, etc., can reduce renal blood flow, uric acid excretion is reduced. 7, some of the anti-tuberculosis drugs tuberculosis patients for a long time with pyrazinamide and ethambutol and not with rifampin, most patients with elevated blood uric acid, but also often induced gout. Pyrazinamide and ethambutol both inhibit the excretion of uric acid and increase blood uric acid, but rifampicin has a better effect on the arthralgia caused by pyrazinamide, which may be related to the inhibition of uric acid absorption and acceleration of uric acid excretion by rifampicin.