Depression is a common psychological disorder that afflicts humans, and taking antidepressants is a major form of treatment for depressed patients to improve their symptoms and quality of life. However, after a number of studies from 2003 to 2004 concluded that antidepressants may lead to a higher risk of suicide, especially in adolescents, the U.S. Food and Drug Administration (FDA) issued a warning in 2004 and mandated that pharmaceutical companies place prominent black warning labels on the packaging of certain antidepressants. Antidepressants may also lead to a higher risk of suicide in adults and therefore require close monitoring of those taking them. So, do antidepressants really increase the risk of suicide and cause people to take them? This needs to be analyzed in terms of both the characteristics of the person taking the medication and the antidepressant. In addition to depressed mood, some patients may also have significant anxiety and agitation symptoms, while others show significant psychomotor depression, with little speech, movement, food, or even no speech, movement, or food; some show significant feelings of despair and self-criminality, while others show significant physical dysfunction, with decreased appetite, sexual desire and sleep disorders. Some patients may have strong suicidal ideation and may act on it, while others may have suicidal ideation but never act on it, and some may never have suicidal ideation; depression in the elderly may not show obvious depressive experience, but rather show the so-called “insidious depression” which is mainly physical discomfort; depression in adolescents may show behavioral disorders and social maladjustment as the main symptoms. In adolescents, depression may be characterized by behavioral disorders and social maladjustment as the main symptoms. From the perspective of antidepressants, most antidepressants take about 2 weeks to take effect in the treatment of depression, and some antidepressants, especially SSRIs (selective 5-hydroxytryptamine reuptake inhibitors), have a certain “activating” effect at the beginning of treatment, which may lead to anxiety, agitation, insomnia and other symptoms. In addition, antidepressant treatment first eliminates the patient’s inhibitory symptoms and physiological dysfunction, and finally improves the patient’s depressed mood. After understanding the disease characteristics of depression and the characteristics of antidepressants, we can analyze the following possibilities for the relationship between antidepressants and suicide: 1. Some depressed patients have very obvious suicidal tendencies and have already experienced suicidal behavior before treatment, regardless of the treatment they receive and whether they take antidepressants or not. The suicidal behavior that occurs in this case is obviously not much related to antidepressants. 2, antidepressants generally take about 2 weeks from the start of use to take effect, in this 2-week period, the patient’s condition may still be developing, although there was no suicidal behavior before taking the drug, but due to the development of the disease and suicidal behavior, which inevitably gives the false impression that antidepressants will lead to suicide, but in fact, suicide in this case also does not have much to do with antidepressants. 3, some antidepressants in the early stage of treatment due to its “activating” effect and lead to anxiety symptoms, while the patient’s depressive symptoms have not yet improved, this “activating” effect of drugs in a way will “worsen” the condition, increasing suicide. This “activating” effect of the drug can somehow “worsen” the condition and increase the risk of suicide. Because in addition to depression, strong anxiety is also an important cause of suicide. 4, because antidepressants first eliminate the patient’s inhibitory symptoms, and finally improve the patient’s depressed mood, in the depressed mood is not eliminated, the original suicidal ideation still exists, and inhibitory symptoms have been completely lifted, the patient is more likely to commit suicide at this time. 5, there are many causes of suicide, in addition to mood disorders, other factors such as stressful life events can also cause suicide, if patients appear suicidal behavior during medication for other reasons, apparently suicide is related to the disease or medication, but in fact there is no connection. In fact, many studies have shown a strong association between the use of SSRI antidepressants and a decrease in suicide rates. Although it cannot be completely ruled out that antidepressant use increases the risk of suicide, it is certain that suicidal behavior in patients taking antidepressants is more often related to their own disease characteristics. Therefore, when antidepressants are used to treat depression, patients’ disease characteristics should first be fully understood and their suicidal risk should be assessed, and changes in their condition should be closely observed during medication use, especially in the early stages of treatment and when patients are in partial remission of their symptoms, which requires increased monitoring to prevent suicidal behavior. It is recommended that patients should be systematically treated with antidepressants under the guidance of a physician and avoid self-administration and self-adjustment of medication doses.