Syphilis is a highly contagious disease that is one of the eight major sexually transmitted diseases, with sexual, maternal, and blood contact being the main means of transmission. If syphilis is not treated promptly and effectively, it can lead to meningeal vasculopathy, spinal cord consumption, paralytic dementia and other co-morbidities, and in severe cases, death. The diagnosis of syphilis requires serological testing for syphilis, antibody testing for syphilis spirochetes, dark field microscopy, molecular biology syphilis testing and cerebrospinal fluid testing. The cost of the examination needs to be determined by the doctor according to the examination items prescribed by the patient, and the cost of different instruments and examination items varies, ranging from a few hundred to a thousand. The main symptom of syphilis is the appearance of hard chancre, while syphilis stage 2 and syphilis stage 3 will show symptoms such as syphilis rash, fever and physical weakness. The treatment for syphilis mainly takes penicillin injection, if you are allergic to penicillin, you can use erythromycin or tetracycline for treatment. After the standard treatment of early syphilis, regular retesting should also be carried out at 3 months, 6 months and 1 year. After unclean sex, once the body appears rash, ulcers and other symptoms, should promptly go to the hospital for a comprehensive systematic examination, timely detection, early intervention, to reduce the damage to the body.