The side effects of antidepressant drugs are relatively minor, the probability of occurrence is relatively low, so you can use them with confidence and do not be too nervous. The first line of antidepressants commonly used in the current situation is recommended for selective 5-hydroxytryptamine reuptake inhibitors, such as sertraline, fluoxetine, paroxetine, citalopram and so on, which are more effective, faster-acting and have fewer side effects. Common side effects such as gastrointestinal reactions, that is, nausea, vomiting, upper abdominal discomfort, diarrhea, constipation, etc. These gastrointestinal reactions are usually more common in the first week of taking the drug, and then will slowly disappear. Some other side effects may occur, such as dizziness, anxiety, irritability, or the possibility of transient mania after long-term use, that is, to manic episodes. There are also dual-channel antidepressants, such as duloxetine and venlafaxine, which may have an effect on blood pressure, so care and caution are needed. Some old antidepressants, such as monoamine oxidase inhibitors, tricyclic antidepressants and so on, have more side effects and are rarely used in clinical practice.