Some people say that the amount of alcohol can be trained to be large by later training. Is this claim reliable? Let’s look at the metabolic pathway of alcohol in the body! The main component of alcohol – ethanol is mainly metabolized by ethanol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), ADH is able to metabolize digoxin, trichothecene, 3-keto derivatives, gitoxin and other digitalis compounds in addition to ethanol in the body, and is a detoxifier in the human body. Acetaldehyde is the culprit of damage to the human body after drinking alcohol, and by covalently binding to many proteins, it can impair the catalytic function of many enzymes, interfere with DNA synthesis and repair, and has highly toxic, mutagenic and carcinogenic effects on human tissues and organs. In addition, some people’s flushing and even allergic reactions after drinking are also the effect of acetaldehyde. Both enzyme activities are high, alcohol can be rapidly turned into acetic acid in the body and metabolized and discharged. This is the real “alcoholic”. The high activity of ADH rapidly converts ethanol into acetaldehyde, which accelerates the heart rate, dilates the peripheral blood vessels, increases cardiac output, and causes facial flushing. In this population, if ALDH is inactive in the body, toxic acetaldehyde can only be metabolized in the liver, while P450 is also an important detoxifying enzyme in our body. People with no activity of both enzymes are often suddenly drunk. Therefore, we can see that in people with low activity of both “detoxification enzymes”, the alcohol consumed can only be metabolized slowly by the liver. The detoxification enzymes of the liver, when a large amount of alcohol enters the body, will tend to focus on the detoxification of ethanol and acetaldehyde and reduce the detoxification of other toxic substances, so the more you drink, the more obvious the tendency of the detoxification enzymes in the liver to focus on detoxification, creating the illusion of “the more you drink, the more you can drink”, making people believe that the amount of alcohol can be trained through The more detoxifying enzymes in the liver, the more obvious the tendency to focus on detoxification. Unbeknownst to us, such “training” is based on serious liver damage! Drunkenness is alcohol poisoning, the central nervous system from excitement to inhibition, and damage to the liver, kidneys, stomach, spleen, heart and other important organs of the human body, most commonly liver cirrhosis, peripheral neuropathy and epileptic seizures, and some form alcoholic mental disorders and alcoholic encephalopathy. Severe cases can lead to death. In addition, long-term alcohol consumption is also associated with tumorigenesis in various organs and organs throughout the body, especially in increasing the susceptibility to gastrointestinal cancers such as liver and rectal cancers synergistically. The ADH1B and ALDH2 genes are alcohol enzyme-related genes, and alteration of a polymorphic site in these two genes affects the activity of both enzymes. Therefore, 85% of a person’s alcohol consumption is determined innately and not trained later in life. By testing polymorphisms in the ADH1B and ALDH2 genes and evaluating the level of activity of ADH and ALDH, an individual’s tolerance to alcohol can be evaluated. Are you really able to drink? Or is your liver taking a lot of damage for your “massive amount”?