The reference value of indirect bilirubin is 3.4-17.0μmol/L. 17.7μmol/L indicates a high value of indirect bilirubin in the blood. The hazards include the following two kinds: 1, physiological factors: usually does not cause serious damage to the body; if the indirect bilirubin continues to rise, it can cause obvious effects on the liver; the blood-brain barrier function of newborns is not yet perfect, so high indirect bilirubin may lead to jaundice, and can also affect the hearing, vision, movement and intelligence of newborns, and even cause irreversible damage to the central nervous system 2, disease factors: patients with hemolysis may cause coagulation disorders and renal insufficiency; patients with cirrhosis may cause hepatic decompensation and portal hypertension; patients with primary liver cancer may also seriously affect the survival of patients. In conclusion, if the indirect bilirubin test result is high, but there are no symptoms, signs and other imaging and hematological abnormalities, most of them are not clinically significant and are a normal phenomenon, which can be reviewed on a regular basis. If the indirect bilirubin rises gradually on the basis of 17.7 μmol/L, the possibility of disease, such as hepatocellular damage or hemolytic lesions, should be considered at this time.