It is very important to strictly control the intake of high purine foods. It is generally believed that animal offal, broth (long stewed meat makes most purines into the soup), beer, etc. have the highest purine content, followed by most fish, shellfish, meat and poultry. Among vegetables, asparagus, cauliflower, string beans, beans, spinach, mushrooms, peanuts, etc. contain more purines. Also pay attention to drink more water. Blood uric acid and body mass index are positively correlated, so you should control the total daily calorie intake and reduce weight. Binge drinking and overeating are strictly prohibited. 1.Treatment principles of gout: ① Rapid resolution of pain; ② Prevention of recurrence; ③ Prevention of gout stones and joint damage; 2.Treatment of gout attacks Non-steroidal anti-inflammatory drugs (NSAIDS), colchicine, and glucocorticoids, the effect of which depends on when the drug is given. If given immediately at the onset of the attack, symptoms tend to disappear quickly, and if not given within 48 hours, it takes about 2 days for them to become effective. Once it is effective, the dose can be gradually reduced after the symptoms have disappeared, and the drug can be stopped after 48 hours. (1) NSAIDS: Indomethacin is most commonly used. Generally NSAIDS should be given from the maximum recommended dose, and once it takes effect, the dose reduction should be started. Note use with caution if you have peptic ulcers or renal insufficiency. Celecoxib capsules (Celebrex) 0, 4 qdpo. (2) Colchicine: Generally 0, 5 mg/h ~ 0, 6 mg/h dose is started orally until one of three symptoms appear: ① clinical symptoms improve significantly; ② significant gastrointestinal symptoms, such as abdominal distension, nausea, vomiting, diarrhea, etc.; ③ Colchicine can also be used intravenously, especially for patients who cannot take it orally, usually with 20ml to 50ml of saline dilution, 15 to 20 minutes input finished. However, it is important to note that once it leaks out, it can cause serious damage to the tissue. No more than 2mg should be given intravenously at one time, and no more than 3mg of colchicine should be given in 24 hours for a single gout attack. if given intravenously, no further colchicine should be given in any form within 7 days. Colchicine is not recommended to be given intravenously if there is concurrent liver or kidney disease. Note that incorrect use of colchicine can lead to death. (3) Hormones: are usually given when colchicine and NSAIDS are not available. The dose is 20mg/d to 40mg/d. After the symptoms are relieved, the drug is stopped within 1 to 2 weeks. Intra-articular injections of 10mg to 40mg of prednisone or fludrocortisolone (triamcinolone) can also relieve symptoms. Generally one of the above drugs can solve the acute attack of gout, but very serious patients are sometimes ineffective. 3, gout attack prevention patients can use small doses of colchicine or NSAIDS to prevent. The preventive dose of colchicine is 0,5mg to 0,6mg once to three times a day. Long-term application of colchicine can lead to neuromuscular symptoms and renal decompensation, especially in elderly patients. Therefore, if the blood creatinine is >133 mol/L, the daily amount of colchicine should not exceed 0, 6 mg. 4. The goal of pharmacological treatment of hyperuricemia is to control the uric acid level at 5 mg/dL (300 umol/L). (1) Inhibition of uric acid production: Allopurinol, should be used in patients who have failed to respond to conventional treatment such as diet control, stone recurrence or gout. If renal function is normal, the initial dose of allopurinol should be 100mg/d, gradually increasing to 300mg-400mg, with a maximum dose of 800mg/day. If renal insufficiency is present, the dose should be adjusted at any time. 300mg/d is effective in 85% of patients. (2) Drugs to promote uric acid excretion: ①Propofol (carbenoxolone); ②Benzbromarone is by far the most potent diuretic drug. It can also be taken for patients with severe kidney disease. It is usually well tolerated by patients and can be used for long-term treatment of hyperuricemia and non-episodic gouty arthritis. Benzbromarone tablets (Ligurian): Adults take 50mg (1 tablet) once daily after breakfast and check blood uric acid concentration after one week; or 100mg (2 tablets) daily after breakfast at the beginning of treatment and change to 50mg (1 tablet) daily when blood uric acid drops to normal range. ③Sulfopiridone (thioxazone). ④Iodofuranone: It can be used for allopurinol allergic patients and has better uric acid-lowering effect than allopurinol in renal transplant patients. ⑤Closartan: In addition to lowering blood pressure, this drug has the function of promoting uric acid excretion. (3) Uric acidase drugs: Intravenous injection of uric acidase drugs can break down uric acid into allantoin. (4) Others: Promote intestinal excretion of uric acid drugs: such as some activated charcoal-based adsorbents, which are effective in combination with allopurinol. Aixit (medicinal charcoal tablets), 3-10 tablets, tidpo Special note: Treatment of gout stones after breakage: remove uric acid salts from the nodule as much as possible, flush the wound with saline daily, apply erythromycin ointment and cover it slightly with sterile gauze.