The nemesis of scleroderma is not white wine. Scleroderma is a connective tissue disease characterized by localized or widespread hardening of the skin and progressive sclerosis of internal organs. White wine for scleroderma is not scientific, diagnosed with scleroderma should be timely to the regular hospital treatment, is not recommended to believe in the so-called prescriptions, so as not to delay the condition. Scleroderma may be related to genetic factors, environmental factors, infectious factors and so on. It often manifests itself as damage to the skin, which can show symptoms such as edematous erythema, grayish-white spots, and increased or decreased skin pigmentation. It can also cause multi-system lesions, which can manifest as Raynaud’s phenomenon, mask face, dysphagia and dyspnea. White wine is an alcoholic beverage and there is no evidence that it has a therapeutic effect on scleroderma. Early stage scleroderma can be treated with topical application of medications such as calcipotriol ointment, tacrolimus ointment, and cumquat chloride ointment. For patients with acrodermatitis and Raynaud’s phenomenon, nifedipine, captopril, and vitamin E can be considered to relieve symptoms. All of the above medications should be used as prescribed. When the appearance of scleroderma, it is recommended to seek timely medical treatment, further improve the relevant examination, under the guidance of the doctor for targeted treatment or treatment.