People with depression often ask their doctors when they visit them, what causes depression? Some doctors will answer that it’s a deficiency of a little something in the brain called neurotransmitters. So what are neurotransmitters? Neurotransmitters are classical chemical messengers. When a presynaptic neuron is excited, it rapidly releases neurotransmitters and immediately binds to the postsynaptic or presynaptic cell membrane, thus causing an excitatory or depressive effect. In the brain and nervous system, information is transmitted between neurons by neurotransmitters, so it is the neurotransmitters between neurons that are prone to problems. Neurons are electrically transmitted, and between two neurons Neurons are electrical energy transmission, while between two neurons need to be converted to chemical energy by neurotransmitters transmission, if something goes wrong with neurotransmitters and its receptors, it will affect the transmission. What does the neurotransmitter theory mean? The neurotransmitter theory refers to the monoamine hypothesis, which states that the onset of depression is closely related to low levels of monoamines such as NE and 5-HT in the brain. However, this hypothesis cannot explain many phenomena. For example: some drugs that increase monoamines do not have antidepressant activity; not all antidepressant patients respond to the same antidepressant; antidepressants raise monoamines in the brain in a few hours, while their antidepressant efficacy takes 2-6 weeks to develop. In response to these phenomena, the modern monoamine hypothesis suggests that antidepressant therapeutic effects are closely related to long-term adaptive changes in monoamine self and heterologous regulatory receptors. How should we understand the neurotransmitter theory? The human being should be understood as a whole. There are hundreds of neurotransmitters and neuromodulators found in the whole human nervous system, and any stimulus will cause a coordinated response of the nervous system, which should involve multiple neurotransmitters. The neurotransmitter theory that depression is only related to monoamines, and the current antidepressants are also mainly related to monoamine regulation, is obviously somewhat inadequate. Any stimulus can cause depletion of neurotransmitters. Chronic stimulation or excessively intense stimulation that causes excessive neurotransmitter depletion beyond the body’s normal ability to recover, or even failure to recover, can cause neurotransmitter deficiency. At the same time, energy transmission is affected, and anxiety and depression manifestations occur. Treatment with antidepressants mainly restores neurotransmitters between neurons, but drug recovery is accompanied by a reduction in possible depletion and stimulation of the nervous system by various factors. This involves psychotherapy, psychological counseling, physiotherapy, appropriate Chinese medicine treatment. As well as the development of good habits, proper exercise, cultivation of the body, and especially the control of accidental cerebral exertion. Gradually, the body is allowed to return to its normal physiological state. Let the nervous system operate within the physiological function.