Meet the new antidepressants

  I. It is a novel variety of antidepressant drugs.  The pharmacological mechanism is different from existing SSRIs, SNRIs, NASSAs, and MAOIs and TCAs, etc. It is a melatonin MT-1 and MT-2 receptor agonist; and a 5-HT2c receptor antagonist.  The specific pharmacological mechanisms are as follows: 1. Acts on MT-1 and MT-2 receptors in the supraoptic nucleus to improve sleep.  2. Acting on 5-HT2c leads to increased DA and NE function in the prefrontal cortex and treats depression.  3, Studies have also found increased neurotrophic factors in the hippocampal region and increased hippocampal volume, which may help improve memory function.