Finger nails with vertical lines do not confirm the diagnosis of a specific disease. Many physiological and pathological factors can lead to the appearance of vertical lines on the nails, and the cause should be clarified and treated as soon as possible if necessary. Human finger nails are formed by keratinized proteins, and due to the selective expression of genes, each person’s finger nails are different. Part of the population nail protein keratinization process can appear vertical lines, in addition to the nails by external forces, extrusion, trauma, in the process of recovery can also appear vertical lines on the finger nails, these are normal physiological phenomena, is not a manifestation of the disease, harmless to the human body, no need for treatment, generally can be naturally subside. Such as poor nutritional status, lack of vitamins, calcium, iron and other elements, can affect the synthesis of nail keratinization proteins, at this time there can be vertical lines on the nails; in addition, some of the nails of the malignant tumors can change the shape of the nails, the appearance of vertical lines on the nails. Therefore, the appearance of vertical lines on the nails does not confirm the diagnosis of a particular disease, and it is important to clarify the cause of the disease in a timely manner, and to treat the disease as soon as possible under the guidance of a professional physician in order to improve the prognosis of the patient.