At present, there are mainly eight kinds of drugs or methods to deal with hepatitis B virus in China, which we call “eight nemesis”. All hepatitis B virus infected patients should understand the advantages and disadvantages of these eight types of treatment methods, and carry out individualized treatment under the guidance of specialists to achieve the best therapeutic effect: (1) Hepatitis B vaccine: Hepatitis B vaccine is a kind of medication used for preventing hepatitis B infection, and hepatitis B vaccine can produce hepatitis B surface antibody in the body of the vaccinee, so as to achieve the purpose of preventing hepatitis B infection. Therefore, hepatitis B vaccine is known as the nemesis of preventing hepatitis B virus infection. It has been proved that hepatitis B vaccination is the most effective way to prevent HBV infection. The Ministry of Health of China included hepatitis B vaccine into the management of planned immunization in 1992, and all newborns were inoculated with hepatitis B vaccine, but the vaccine and its inoculation fee had to be paid by parents; since 2002, it was formally included into the management of planned immunization, and all newborns were inoculated with hepatitis B vaccine free of charge but had to pay for the inoculation fee, and since June 1, 2005, it was changed to be completely free of charge. Since China has gradually implemented the management of hepatitis B vaccination for newborns, obvious results have been achieved, and the population infected with the hepatitis B virus in China has dropped from the previous 10% to 9.09%, so the number of newborns infected with hepatitis B will be less and less. However, it is worrying that due to various reasons, there is still a large part of adults who have not been vaccinated against hepatitis B. They either do not know that hepatitis B infection can be prevented by way of hepatitis B vaccination, or they do not know that a course of hepatitis B vaccine is only about one hundred dollars or they mistakenly believe that the hepatitis B virus will not be infected easily, and so on. (2) Interferon: Interferon (IFN) is a kind of protein produced by human cells under certain stimuli, which has broad-spectrum antiviral effect, anti-tumor proliferation and immunomodulatory effect. Interferon does not directly kill or inhibit viruses, but rather inhibits viral replication by causing cells to produce antiviral proteins through the action of cell surface receptors; at the same time, interferon also enhances the vitality of natural killer cells, macrophages, and T-lymphocytes, thus regulating the body’s immune function. Now it is proved that 3% of patients can achieve surface antigen conversion after 48 weeks of treatment of hepatitis B with long-acting interferon, Pyroxin, and the percentage increases to 8% when the drug is discontinued and followed up for 3 years. Therefore, we call interferon as the nemesis to enhance immunity and inhibit the replication of hepatitis B virus. (3) Nucleoside analogs: Nucleoside analog (NA) antiviral drugs are a class of antiviral drugs that have developed rapidly in recent years, and there are dozens of drugs that have been and will be introduced into the clinic. Lamivudine, as the first approved oral anti-HBV drug, was introduced to promote the process of chronic hepatitis B treatment, marking the entry of chronic hepatitis B treatment into the era of nucleoside analog therapy. Lamivudine is a nucleoside analog, and nucleotides are the raw materials for the synthesis of DNA and RNA, the genetic material of the human body (DNA and RNA are actually many nucleotides lined up in a long string hand in hand). Nucleoside analogs mimic the structure of nucleotides in structure, but do not have the function of nucleotides. Therefore, during DNA synthesis, nucleoside analogs can be incorporated, but they cannot synthesize nucleic acid chains with normal functions, thus terminating viral replication. As HBV enters the liver to form CCCDNA, nucleoside analogs can only inhibit the replication of the virus, but can not completely eliminate the hepatitis B virus, therefore, nucleoside analogs are known as interference synthesis, inhibit the replication of the hepatitis B virus nemesis, need to be applied for a long time, or even lifelong use. (4) Immunomodulators: current anti-HBV drugs such as interferon and nucleoside analogs can only inhibit HBV replication, but not completely eliminate HBV in the body, therefore, the relapse rate is higher after stopping the drugs. Immunomodulators can improve the body’s immune function, especially specific immunity to HBV. It can recognize and destroy the target cells of HBV infection and clear HBV.Numerous studies have proved that chronic hepatitis B suffers from low immune function, especially reduced specific immunity to HBV and immune tolerance, as well as abnormal immunomodulatory function, which prevents HBV from being cleared from the human body.Therefore, it is very important to apply effective immunomodulators in antiviral treatment of chronic hepatitis B to improve the immune function of the human body and to break immune tolerance. break immune tolerance, is very important. Therefore, we call immunomodulators the nemesis of hepatitis B virus. (5) Hepatoprotective and enzyme-lowering drugs: Hepatitis B, whether acute or chronic, will have different degrees of hepatocellular inflammation and injury at the onset, if the development of the disease is not controlled, the liver function will be further damaged, the symptoms will be further aggravated, and there will be the development trend of severe hepatitis at any time, and the patient’s condition is critical once severe hepatitis is formed, and his life is in danger at any time. Therefore, in the early stage of the development of hepatitis B, it is necessary to curb further damage to liver function, the application of hepatoprotective and enzyme-lowering drugs at this stage is bound to achieve the effect of guarding as attacking and getting twice the result with half the effort. Not only prevent the further damage of liver cells, but also make the damage of liver cells get a certain degree of repair, so as to cooperate with antiviral and immunomodulation treatment, make the liver function of hepatitis B patients return to normal, and the condition get better, or even completely recovered. Clinical practice also found that, after the use of hepatoprotective and enzyme-lowering drugs, if the patient’s liver function can be stabilized for a long period of time, it will rely on the gradual establishment and improvement of the patient’s own immune function, and it also has a certain inhibitory effect on hepatitis B virus. Therefore, it can be said that hepatoprotective and enzyme-reducing drugs are the nemesis of hepatitis B virus which takes defense as offense. (6) Chinese medicine: although there is no “viral hepatitis” in Chinese medicine, as early as two thousand years ago, Zhang Zhongjing’s “Treatise on Miscellaneous Diseases of Typhoid Fever” had the record of “seeing the disease of the liver, knowing that the liver spreads to the spleen, and it is the first thing to do to make the spleen real”, which means that at that time, people had already recognized that “Liver disease” can show “digestive symptoms”. In Chinese medicine, there are “coercive pain”, “jaundice”, “accumulation of symptoms” and “bulging”, “Blood evidence”, “epidemic poison”, “liver plague” and other diseases, in fact, has included the “viral hepatitis” of the Based on the method of identification and treatment, Chinese medicine can at least achieve the following effects in the treatment of chronic hepatitis B: improving symptoms and quality of life, preserving the liver and lowering enzymes, reducing yellowing and anti-inflammation, as well as certain anti-fibrosis, cirrhosis and hepatocellular carcinoma, and certain anti-viral effects. Therefore, we call traditional Chinese medicine as the nemesis of hepatitis B virus invented by Chinese people. (7) Food therapy: “medicine and food have the same origin”, food and medicine have the same cold, hot, warm, cool “four qi” and pungent, sweet, sour, bitter, salty “five flavors”, if we can follow the principle of TCM evidence-based food selection, then we can choose the right food for you. If you can follow the principle of Chinese medicine to identify the food, you can correct the bias of the yin and yang of the internal organs, to achieve the prevention and treatment of diseases and enhance the health of the body, anti-aging and prolonging the life of a variety of purposes, which is the Chinese medicine of food therapy. Diet and nutrition in the prevention and treatment of liver disease has a positive and important role, such as the skillful use of traditional Chinese medicine diet therapy, according to the different tonic effect of food, to guide the patient according to their own specific disease “identification of food”, not only to achieve the purpose of supplemental nutrients, but also to improve the patient’s clinical signs and symptoms, to promote the enzyme indexes of liver function are positive therapeutic effect. It can not only achieve the purpose of supplemental nutrition, but also have positive therapeutic effect on improving clinical symptoms and signs, promoting the improvement of liver function enzyme indexes. Therefore, diet therapy can be called the nemesis of hepatitis B virus in the daily life of hepatitis B patients. (8) Therapeutic Hepatitis B Vaccine: One of the reasons why chronic hepatitis B is difficult to treat is that the body has developed a certain degree of specific immune tolerance to hepatitis B virus (HBV). The absence of an immune response to HBV allows the pathogenic microorganism to persist in the body. The development of a therapeutic hepatitis B vaccine was conceived in the hope of mobilizing the body’s immune response against the virus in the body. Therapeutic Hepatitis B vaccines are natural, synthetic or recombinantly expressed products or products that treat or prevent the progression of a disease by inducing a specific immune response in an organism infected with a pathogenic microorganism or suffering from a certain disease. The advantage of the therapeutic hepatitis B vaccine is that it “teaches” the body’s immune system to correctly recognize the hepatitis B virus as an enemy lurking in the body, and mobilize the body’s own immune system to reduce the replication ability of the hepatitis B virus and eliminate it from the body. However, this treatment method is still in the process of clinical research, not yet officially used in the clinic, the industry agreed that this is a promising hepatitis B virus nemesis.