Osteoporosis brings great inconvenience and pain to patients’ lives, and the treatment is very slow, once the fracture can be life-threatening, therefore, special emphasis should be placed on the implementation of the three levels of prevention. 1, primary prevention: should start from children and adolescents, such as pay attention to reasonable dietary nutrition, more food containing high Ca, P, such as fish, shrimp, shrimp, kelp, milk (250ml contains Ca300mg), dairy products, bone broth, eggs, beans, refined grains, sesame, melon seeds, green leafy vegetables, etc.. Try to get rid of “risk factors”, adhere to a scientific lifestyle, such as adhere to physical exercise, more sunbathing, do not smoke, do not drink alcohol, less coffee, strong tea and carbonated beverages, less sugar and salt, animal protein should not be too much, late marriage, less childbearing, breastfeeding period should not be too long, as far as possible to preserve the calcium in the body, enrich the calcium pool, the bone The best measure to prevent osteoporosis in the later stages of life is to increase the peak value of calcium to the maximum. Strengthen the basic research of osteoporosis, and focus on the follow-up and early prevention for the high-risk groups with genetic predisposition. 2.Secondary prevention: bone loss accelerates in middle age, especially after menopause in women. Bone density examination should be conducted annually during this period, and prevention and control measures should be taken early for people with rapid bone loss. In recent years, most scholars in Europe and the United States advocate starting long-term estrogen replacement therapy within 3 years after menopause, while insisting on long-term preventive calcium supplementation to safely and effectively prevent osteoporosis. In Japan, most advocate the use of active Vit D (rocalciferol) and calcium to prevent osteoporosis, and pay attention to the active treatment of diseases related to osteoporosis, such as diabetes, rheumatoid arthritis, steatorrhea, chronic nephritis, hyperparathyroidism/hyperthyroidism, bone metastatic cancer, chronic hepatitis, liver cirrhosis, etc. 3.Tertiary prevention: Patients with degenerative osteoporosis should be actively treated with drugs that inhibit bone resorption (estrogen, CT, Ca) and promote bone formation (active Vit D), and should also strengthen measures to prevent falls, bumps, trips and upsets. For middle-aged and elderly patients with fractures should be actively operated, implement strong internal fixation, early activity, physical therapy, physiotherapy psychological, nutrition, calcium supplementation, pain relief, promote bone growth, curb bone loss, improve immune function and overall quality and other comprehensive treatment. Degenerative osteoporosis is the basic law of bone development, growth and aging, but is subject to hormonal regulation (mainly PTH bone breaking: estrogen, CT osteogenesis; Vit D3 two-way regulation), nutritional status, physical factors (sunlight, weight), immune status (systemic physique, disease), genetics, lifestyle (smoking, alcohol, coffee, eating habits, exercise, mental and emotional), economic and cultural If we can strengthen the awareness of self-care, improve the level of self-care and actively intervene scientifically, it is possible to delay and prevent degenerative osteoporosis, which will have important and realistic social and economic benefits to improve the physical and mental health and quality of life of hundreds of millions of middle-aged and elderly people in China.