The preferred antihypertensive drugs commonly used in patients with polycystic kidney are angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists, also known as ACEI and ARB drugs, and this class of drugs includes captopril, ramipril, valsartan, irbesartan, and coxsartan. Blood pressure can also be controlled with antihypertensive drugs such as diuretics, calcium channel antagonists, and alpha and beta receptor antagonists. For hypertensive disease that cannot be controlled by medications, renal cyst decompression and nephrectomy may be considered. Since hypertension is one of the risk factors leading to the deterioration of renal function in patients with polycystic kidney, the blood pressure of patients with polycystic kidney should be controlled as much as possible within the target value, which is 130/80 mmHg.