Scleroderma’s nemesis is an understatement. Scleroderma is an autoimmune disease that requires an aggressive and standardized treatment approach in order to achieve control of the disease. Scleroderma commonly used treatment methods immunotherapy, vascular lesion treatment, anti-fibrosis and other treatments. 1. Immunotherapy: Scleroderma is an autoimmune disease. Non-selective immunosuppressants are commonly used to treat scleroderma-specific organ damage. Commonly used immunosuppressants include cyclophosphamide, merti-macrolide, azathioprine, methotrexate and tacrolimus, etc. Contraindications need to be excluded before use of the drugs and the drugs need to be used in accordance with the doctor’s instructions. 2. Treatment of vascular lesions: Scleroderma often has serious vascular lesions, and vasodilators such as nifedipine or antiplatelet drugs such as aspirin can be used to improve the vascular lesions as prescribed by the doctor. At the same time, pay attention to keep the limbs warm. 3. Anti-fibrotic treatment: For patients with skin thickening and visceral fibrotic lesions, anti-fibrotic treatment is needed. However, there is no effective drug to reverse the fibrosis process. It is recommended that patients with scleroderma should go to the rheumatology and immunology department in time for treatment under the guidance of doctors and regular follow-up.