The total course of treatment for duodenal ulcers is 6 weeks, which means that it takes at least 6 weeks to completely heal a duodenal ulcer. If the patient has a healing ulcer, this treatment time can be reduced accordingly. If the patient has a definite active ulcer on the gastroscope, a regular course of medication is required. This 6-week treatment period includes 2-4 weeks for PPI drugs and 4-6 weeks for bismuth drugs. If the patient has H. pylori infection, the patient also needs to be given a regular quadruple therapy regimen for H. pylori eradication, and the treatment course for Hp eradication is 10-14 days. Patients need to consult a specialist for specific medications, and after the end of treatment, they also need to review the electronic gastroscopy to clarify whether the ulcer is completely healed, and if necessary, the treatment time should be extended.