Indirect bilirubin is mainly from the destruction of red blood cells, not in the liver after glucuronidation is called indirect bilirubin, the normal reference value of 3.4-17.0μmol/L, indirect bilirubin 22.9μmol/L, can indicate high bilirubin. The clinical significance of elevated indirect bilirubin is seen in: 1, liver diseases, certain malignant diseases can also lead to elevated indirect bilirubin in the blood, such as acute jaundice hepatitis, acute liver necrosis; 2, hemolytic anemia, a large number of red blood cells in the human body destroyed, too much indirect bilirubin in the blood, more than the conversion capacity of the liver, so that the indirect bilirubin in the blood stagnation, thus causing an increase in indirect bilirubin, this situation This condition is called hemolytic jaundice; 3, blood type incompatibility transfusion, when blood type incompatibility, blood input into the body will lead to hemolysis, so that a large number of destruction of red blood cells in the liver, which leads to elevated indirect bilirubin in the blood; 4, hepatocellular jaundice, because bilirubin can not be converted into bile normally, or by the swelling of liver cells, so that the bile ducts in the liver are under pressure, bile excretion is under pressure, so that the bilirubin in the blood is elevated. If the diagnosis of hematologic disease or hemolytic disease is clear, further examination and treatment in hematology or general internal medicine is required. If there is an increase in indirect bilirubin combined with an increase in direct bilirubin, hepatitis or impaired liver function may be considered, which should be further examined and treated by the hepatology department.