Osteoporosis is a skeletal disease characterized by low bone mass with damage to the bone microarchitecture, making a person susceptible to fractures without trauma or with minimal trauma. The picture above shows an osteoporotic vertebral body. The fragility of the trabecular structure leads to mechanical impairment and collapse of the intervertebral disc into the deep bone. This fragility indicates a reduction in the total amount of bone within the vertebral body and a disruption of the normal trabecular microstructure, as clearly evidenced by the cavity at the site of bone loss. Scanning electron micrograph of normal and osteoporotic bone trabecular structures. In patients with osteoporosis, slender rod-like trabeculae have replaced the normal lamellar trabeculae. The fracture of the trabeculae leads to loss of continuity and connectivity of the trabeculae and consequent irreparable destruction of the microstructure and quality of the vertebral body.