Most thyroid nodules have no obvious manifestations at the beginning, some inflammatory nodules, may have local redness and pain. Thyroid nodules are one of the common clinical endocrine system diseases, the main cause is still abnormal proliferation of thyroid tissue, common stimulus is abnormal iodine intake, common nodular lesions: inflammatory nodules, thyroid cysts, nodular goiter, malignant nodules, etc. Inflammatory nodules are usually induced by inflammation in other systems and are often accompanied by other symptoms such as fever, chills, etc. Local redness, swelling and pain may appear, and local symptoms may slowly subside as the inflammation subsides and oral medication is administered. The initial cyst is relatively small and the patient has no obvious sensation or symptoms. As the cyst increases, it may appear as a round mass in the neck with a cystic sensation when pressed. In patients with nodular goiter, there is no obvious manifestation at the beginning, and later irregular nodules in the thyroid area may be found, either unilaterally or bilaterally. Some patients may have symptoms such as hyperthyroidism and hypothyroidism due to abnormal secretion of thyroid hormones, which are detected during the examination. In patients with malignant nodules, the early symptoms are also not obvious. As the nodules increase in size and nearby lymph node tissues metastasize, nodules may be found in the thyroid area of the neck as well as in the surrounding area, and the diagnosis can be further clarified by ultrasound as well as other tests. In conclusion, most thyroid nodules have no obvious manifestations or symptoms at the beginning, so it is recommended to have regular annual medical checkups to detect problems early and intervene early.