Liver transplantation is the only means of treating end-stage liver disease and is the best treatment of choice for early-stage liver cancer based on cirrhosis. All patients who cannot be cured by traditional medical or surgical methods, who have very poor quality of life, who are not expected to avoid death in the near future (6-12 months), and who have no contraindications to liver transplantation can be candidates for liver transplantation. There are five specific categories: 1. Substantial liver diseases caused by non-pathogenic microorganisms. Such as alcoholic cirrhosis, acute and chronic liver failure caused by drugs and chemical toxins, and severe irreversible trauma. 2.Hepatitis and cirrhosis caused by various pathogenic microorganisms leading to liver failure, portal hypertension. 3, congenital metabolic disorders. Such as glycogen accumulation disorder, a1-antitrypsin deficiency, familial non-hemolytic jaundice, hypertyrosinemia, etc. These diseases are the more common indications for pediatric liver transplantation. 4. Cholestatic diseases. Such as congenital biliary atresia, primary biliary cirrhosis (PBC), sclerosing cholangitis (PSC), secondary biliary cirrhosis, and Calorie’s disease. 5.Liver tumors. Malignant tumors of the liver without extrahepatic metastases and large vessel invasion can also be an indication for liver transplantation. Liver transplantation can be considered when the following complications or laboratory abnormalities occur in chronic liver disease: 1. more than one ruptured esophagogastric fundic variceal bleeding; 2. refractory ascites; 3. recurrent hepatic encephalopathy; 4. hepatorenal syndrome; 5. spontaneous peritonitis; 6. albumin less than 28 g/L; 7. total bilirubin greater than 85.5 umol/l; 8. prothrombin time exceeding normal control by more than 5 seconds or more. This is the current internationally accepted index.