After infection with syphilis, clinical symptoms of stage I syphilis usually begin to appear as early as 2-3 weeks after infection, usually without systemic symptoms, mainly hard chancre and enlarged lymph nodes. Patients with latent syphilis infection have a longer incubation period and can go years or even decades without symptoms. Syphilis is a sexually transmitted disease caused by infection with the syphilis spirochete, and is mainly transmitted through direct sexual contact, blood transmission and vertical transmission from mother to child. For blood-borne transmission, a generalized syphilis rash may appear. After diagnosis, timely treatment of syphilis to avoid the development of advanced syphilis, causing serious health effects, while sexual partners should also be investigated and treated together. Patients with latent syphilis have a long incubation period and may not even show clinical symptoms for a long time, but they are still infectious. Patients with a history of unclean sexual intercourse should consult the dermatology department of a regular hospital in time to do serological testing for syphilis when nodules and ulcers appear on the external genitalia or a painless skin rash appears.