”My thyroid function is normal, so how can I have thyroid-related eye disease? Isn’t this disease caused by ‘hyperthyroidism’?” At the beginning of the year, his family overheard that Mr. Lin’s left upper eyelid margin had shifted upward, causing his left eye to ‘show white’ and making it look like his left eye was bigger and his right eye smaller. But there was no obvious discomfort in his eyes, so Mr. Lin didn’t pay much attention. A few months later, Mr. Lin’s left eye became more aggressive and had a significant protrusion of the eyeball. Mr. Lin was worried that he had “hyperthyroidism” and rushed to the local hospital to check his thyroid function, but the test results were normal. After an eye examination, Mr. Lin was diagnosed with “thyroid-related ophthalmopathy”. The disease is a common orbital disease, the onset of which is the first in the adult group, about 20%, with clinical manifestations such as protruding eyeballs, receding eyelids, bulbar conjunctival edema, eye movement disorders, diplopia, and optic nerve compression. ”Among patients with thyroid-related ophthalmopathy, about 70% have a history of ‘hyperthyroidism’, 5% have ‘hypothyroidism’, and 25% have normal thyroid function for a significant period of time. ” The relationship between the time of onset of thyroid-related eye disease and hyperthyroidism can be divided into three cases: 35% of patients have thyroid-related eye disease followed by hyperthyroidism; 25% of patients have both; “hyperthyroidism” is followed by hyperthyroidism. The percentage of those with “hyperthyroidism” followed by thyroid-related eye disease is 40 percent. “To put it simply, most patients with thyroid-related eye disease have a history of ‘hyperthyroidism’, but some patients with thyroid-related eye disease may not have ‘hyperthyroidism’ or may develop ‘hyperthyroidism’ in the future. ‘.” ”The gender of the disease is slightly unique, with those with combined ‘hyperthyroidism’ being more common in young and middle-aged women, and those with simple eye disease without ‘hyperthyroidism’ abnormalities being more common in men.” According to the experts, patients with ocular signs and normal or even low “A function” are mostly middle-aged and elderly men, with single or bilateral eye disease, mild disease in the early stage, light inflammatory response, atypical clinical symptoms, and mostly poor response to glucocorticoid therapy. In the middle and late stages, the disease is severe, the lesions continue to develop, and fibrotic lesions occur earlier in the extraocular muscles and other tissues. ”Fibrosis of the extraocular muscles is like a bull’s-eye band that loses its elasticity and cannot be contracted freely, so that the patient’s eye movements are restricted, causing the patient to see things out of sync, with diplopia and strabismus. The inflammatory response is obvious, but the orbital soft tissue fibrosis is delayed, and the lesions are easily remitted and recurrent, and sensitive to glucocorticoid treatment.