Scleroderma is a chronic autoimmune connective tissue disease that does not heal on its own, but can be relieved and symptoms controlled with treatment, which includes general treatment and medication. 1. General treatment: quit smoking, avoid trauma, quit drinking, pay attention to keep warm. 2. Drug treatment: (1) Inhibition of collagen synthesis: drugs such as cumenexin and D-penicillamine can be used, and attention should be paid to the observation of adverse reactions in the process of use. (2) Vasoactive agents: such as prazosin, tolazoline, nifedipine, dipyridamole, clopidogrel and so on. (3) Others: small doses of prednisone can be used in systemic scleroderma to reduce edema, etc.; immunosuppressants such as azathioprine, methotrexate, cyclophosphamide, etc. can be used. The above drugs should be used in accordance with medical advice, do not self-medication. Scleroderma patients are advised to go to the regular hospital in time, under the guidance of professional doctors to choose the appropriate drug treatment, so as not to delay the condition.