Treatment of depressive episodes in bipolar disorder may be made difficult by single or high doses of antidepressant therapy that may induce manic or hypomanic episodes, or increase the frequency of cycling, or promote rapid cycling episodes. Therefore antidepressants are used with caution in bipolar disorder depressive episodes. If the depressive symptoms are very serious, and the duration is more than 4 weeks, and the previous episodes are mainly depressive clinical phase, then antidepressants can be used in combination with mood stabilizers, and bupropion without tranquilizer is generally preferred, followed by 5D hydroxytryptophan reuptake inhibitor, and tricyclic antidepressants with strong tranquilizer effect should not be used, and if necessary, second-generation antipsychotic drugs, such as quetiapine fumarate, can be given. If necessary, second-generation antipsychotics, such as quetiapine fumarate, can be given, which can stabilize the mind and change the sleep.