Bipolar disorder has a high rate of co-morbidity with other disorders! It can be co-morbid with somatic diseases or co-morbid with other psychosomatic diseases. 1, and physical disease co-morbidity: (1) thyroid disease and bipolar disorder co-morbidity common hyperthyroidism, easy and manic episodes co-occur, the performance of easy to be impatient, gratuitous tantrums, love to hurry, accompanied by panic, fast heart rate, increased appetite, loss of weight, facial redness, constipation, sleep, and other metabolic symptoms of increased metabolism, thyroid function test T3, T4, such as a significant increase in the TSH decrease and other indexes of the changes, when hyperthyroidism When hyperthyroidism is more serious, it not only increases the risk of hyperthyroidism crisis, but also more likely to have manic episodes, and the two affect each other. There is also a manifestation of hypothyroidism that is more likely to have symptoms of depressive episodes, mainly for physical weakness, lazy speech, little movement, do not think of food, low mood, emotional vulnerability, the serious will appear negative suicidal thoughts, thyroid function indicators suggest that there is also a significant decline in the performance of the T3, 4. When the thyroid function is abnormal, on the one hand, the thyroid function should be timely rechecked, on the other hand, psychiatrists need to judge and assess the emotional state, and if it is consistent with the diagnosis of clinical bipolar disorder, it is more necessary to give treatment. (2) diabetes and bipolar disorder co-morbidities abnormal glucose metabolism or metabolic syndrome and bipolar disorder co-morbidities are also more common, clinical type 2 diabetes co-morbidities bipolar disorder is not uncommon, when the abnormal glucose metabolism, there is a significant increase in the risk of depressive episodes, the manifestation of depression episodes of somatic pain and discomfort, gastrointestinal symptoms and insomnia is more serious, often accompanied by anxiety and even agitation, increasing the difficulty of the treatment; when poor glucose control, or even ketone bodies, or even the emergence of ketosis. When blood glucose control is poor, or even ketosis, it is more likely to be accompanied by symptoms of delirium, so that the symptoms of depression are more like dementia-like clinical phase, especially elderly patients are more likely to be misdiagnosed, delaying the treatment time. (3) Cerebrovascular disease and bipolar co-morbidity 1-3 months after stroke patients are co-morbid bipolar disorder risk moments, cerebrovascular disease susceptibility is more significant, the likelihood of manifestation of depressive episodes is greater, with age, the risk of depressive episodes also increases. (4) Substance or Alcohol Abuse and Bipolar Co-morbidity A significant number of patients with substance abuse (narcotics) and alcohol dependence have a significantly increased risk of co-morbid bipolar disorder, with nearly 40-50% of patients with substance and alcohol abuse co-morbid bipolar disorder, with a higher risk of manic episodes. (5) Others, such as Cushing’s disease and high-dose glucocorticoid use, are prone to manic or depressive episodes and should be carefully identified. 2, and psychosomatic disease co-morbidity (1) anxiety disorder co-morbidity bipolar disorder and anxiety disorder co-morbidity is more prominent, especially in the early stage of the onset of anxiety is more obvious, easy to ignore the diagnosis of bipolar disorder, which panic disorder, generalized anxiety and bipolar co-morbidity is more significant (2) obsessive-compulsive disorder co-morbidity obsessive-compulsive disorder with bipolar disorder co-morbidity is also not uncommon, and even compulsion is often a precursor manifestation of the onset of bipolar disorder. Misdiagnosed as obsessive-compulsive disorder (OCD), the increased risk of turning manic after treatment with anti-obsessive-compulsive drugs also indicates the possibility of co-morbidity.