Glioma is a common intracranial tumor, ranking second among malignant tumors in children. Ninety percent of glioma cases present with increased intracranial pressure, with clinical manifestations such as headache, nausea, vomiting and visual disturbances. Other symptoms include epilepsy, vertigo, adductor nerve palsy, and behavioral and personality changes. The progression of symptoms of glioma is related to the location of the tumor, the degree of malignancy, the growth rate and the age of the patient. The following are the clinical manifestations of glioma. 1.Headache: Headache is often one of the early symptoms. Initially, it is often intermittent, throbbing dull pain and distension, and later, as the tumor increases, the headache intensifies and lengthens, and can become persistent. The headache can be limited or full headache, which often occurs in the early morning or after waking up on an empty stomach, and gradually relieves during the day, and can be accompanied by nausea and vomiting in severe cases. Any factors that cause the increase of intracranial pressure, such as cough, sneeze, stool, etc., can aggravate the headache. When the headache suddenly intensifies, the patient is restless, loudly crying for pain or holding the head with both hands, even knocking the head, accompanied by jet vomiting, followed by coma, this is the aura signal of acute intracranial pressure increase crisis, and emergency treatment measures must be taken. Vomiting: Vomiting is often the first symptom of glioma, mostly occurs in the early morning on an empty stomach, with or without nausea before vomiting, and often accompanied by severe headache and dizziness. Sometimes it is jet-like, mostly caused by the stimulation of the vomiting center by the increase of intracranial pressure. The vomiting of pediatric posterior cranial fossa tumor is early and frequent, and it is often the only early symptom, which is easily misdiagnosed as gastrointestinal disease, so when children have frequent vomiting, they should do detailed neurological examination to prevent missing diagnosis. Optic papillar edema: Optic papillar edema is an important objective sign of increased intracranial pressure, and supratentorial tumors are generally heavier on the tumor side, while both sides of sub-tentorial tumors are more or less the same. The tumor at the bottom of frontal lobe directly compresses the ipsilateral optic nerve causing primary atrophy, while the opposite side causes optic papilledema due to increased cranial pressure. The optic papillar edema may not affect the vision for a long time, but as the optic papillar edema worsens, physiological blind spot enlargement and centripetal narrowing of the visual field and secondary atrophy of the optic papilla occur. Once a paroxysmal black clouding occurs, vision will rapidly decline, and the risk of blindness should be alerted and needs to be treated early. The traditional physical examination also applies to patients with glioma, and fundus examination must be performed to confirm the presence of optic papilloedema during physical examination. 4. Epilepsy: Seizures are mostly caused by direct stimulation or compression of the tumor, with an incidence of about 30%. The incidence of epilepsy is about 30%. Generally, slow-growing low-grade gliomas such as astrocytoma and oligodendroglioma have epilepsy as the first or main symptom, while fast-growing malignant glioblastoma has a low incidence of epilepsy. The incidence of epilepsy is related to the tumor site, with the highest incidence in frontal and temporal lobes, about 80%, followed by frontoparietal, parietal, temporoparietal and temporo-occipital lobes. 5.Other symptoms: The tumor stimulates, compresses or damages the surrounding brain tissues or cranial nerves causing neurological localization symptoms, such as frontal glioma can cause damage to motor area, writing and motor language center, etc., and parietal glioma causes cortical sensory disorder, dyslexia, dyscalculia and computational disorder, etc. Temporal lobe glioma can cause tinnitus and hallucinations, sensory or naming aphasia, and vertigo. Patients with glioma should be aware that grade I and grade II gliomas grow slowly and the brain gradually adapts. Symptoms of glioma may appear singly or in combination, and once symptoms appear, they should go to a regular hospital as soon as possible to receive reasonable examination and proper treatment. The treatment of glioma emphasizes comprehensive treatment i.e. surgery radiotherapy plus immunotherapy.