It is difficult and unreliable to distinguish between benign and malignant thyroid nodules from the medical history or general laboratory tests. The following clues are useful for making a rough determination of whether a thyroid nodule is benign or malignant. Benign nodules are more likely to be: 1. The thyroid nodules of other relatives in the family are benign, such as Hashimoto’s thyroiditis, benign thyroid nodules or goiter; 2. They are accompanied by symptoms of hyperthyroidism such as palpitations, hand tremors, fear of heat, excessive sweating, or hypothyroidism such as fear of cold, swelling, weakness, and dry skin; 3. The thyroid nodules are painful or soft to the touch. Cases in which malignant nodules are more likely are: 1) adolescents younger than 20 years old or older than 70 years old; 2) single nodules in males; 3) multiple x-rays or nuclear radiation or other phototherapy in the neck during childhood or adolescence; 4) thyroid nodules that have had thyroid cancer in the past and then regenerated; 5) thyroid nodules that have existed for many years and have rapidly increased in size in a short period of time; 6) nodules that have recently had voice 7. Family history of thyroid cancer or type 2 multiple endocrine tumors (medullary thyroid cancer, pheochromocytoma, parathyroid hyperplasia or parathyroid adenoma); 8. Thyroid nodules are hard to the touch, have uneven edges, and do not move with swallowing. The above is only a simple assessment of the possibility of benign or malignant thyroid nodules from the medical history, but it does not necessarily fit perfectly. To determine the benignity or malignancy of the nodules, it is necessary to go to the hospital and be determined by a specialist through various tests such as ultrasound, thyroid nodule puncture and laboratory tests.