Glioma surgery technology 1. Intraoperative electrophysiological monitoring-protection of brain function Tumors located in or near functional areas or deep in the brain are very likely to cause damage to nerve cells and their nerve fibers in functional areas during surgical resection, which in turn causes symptoms of neurological deficits and seriously affects patients’ survival cycle and quality of life. Our center is the first in China to carry out intraoperative wake-up anesthesia under functional imaging to guide functional area monitoring, which effectively protects patients’ functions such as motor, language, spatial cognition and digital cognition, and has the largest number of cases in China. At the same time, combined with intraoperative cortical EEG tracing to effectively monitor the epileptic foci, the corresponding epileptic foci can be treated with low-power electrocautery, which can maximize the removal of the tumor and preserve the related neurological functions and reduce the complications of surgery. 2. Cognitive function evaluation-protection of brain function In China, we have cooperated with national key laboratories such as Cognitive Neuroscience and Learning Laboratory of Beihang University, Institute of Psychology of Chinese Academy of Sciences and Institute of Automation of Chinese Academy of Sciences, and were the first to apply brain cognitive function and neuropsychological evaluation technology to the treatment of glioma to protect the postoperative survival quality and quality of life of patients. Preoperative functional magnetic resonance, white matter fiber bundle imaging and intraoperative functional area monitoring Glioma and epilepsy Gliomas often have epilepsy as their first symptom. Intraoperative cortical electroencephalography monitoring of epileptic foci Neuromolecular pathology diagnosis Neuromolecular pathology diagnosis is the diagnosis and typing of glioma at the genetic and protein level, and combined with the histopathological diagnosis, it can better guide the individualized radiotherapy and chemotherapy, targeted therapy, and help determine the prognosis of patients. Antagonism of drug-resistant related protein expression on glioma Functional MRI technology We are the first in China to conduct research on the relationship between glioma and functional areas, and to apply functional MR to determine the efficacy of radiation therapy, chemotherapy, and targeted therapy for glioma, maximizing the use of modern functional imaging technology to protect patient function. Magnetic resonance spectral imaging and perfusion imaging Personalized radiotherapy Using methods such as conformal radiotherapy, we can design more reasonable radiotherapy plans for different tumor nature, grade and corresponding physical condition of patients, inactivate the residual tumor cells after surgery and make the tumor shrink or disappear. Individualized chemotherapy According to the tumor histopathology and molecular pathology, combined with the patient’s physical condition and the results of various auxiliary examinations, a targeted chemotherapy program is designed for different patients, which can more effectively kill tumor cells of different proliferation cycles and prevent tumor recurrence, especially for tumors of infiltrative growth and multifocal growth. Molecular targeted therapy is designed according to the molecular genetic signaling system of glioma occurrence and growth, and the targeted application of target-specific blocking drugs can significantly improve the tumor-free survival of patients, which is one of the most advanced techniques in the treatment of glioma internationally. Currently, the most commonly used molecular targeted drugs for neurological malignancies are VEGF monoclonal antibodies (such as bevacizumab) targeting blood vessels, because tumor growth and proliferation need constant neovascularization to provide, so neovascularization is a characteristic of tumors, and effective inhibition of neovascularization will have a significant therapeutic effect on tumor growth. Meroval for the treatment of lymphoma is an anti-CD20 monoclonal antibody, such as rituximab. In addition, some drugs that act on signaling pathways are commonly used, because tumor growth requires signaling, if the signaling is aborted, the tumor will apoptosis, commonly used drugs such as epidermal growth factor receptor tyrosine kinase inhibitors. At present, the drug treatment of tumor is in the transition period from pure cytotoxic attack to combined treatment with molecular targeting, cytotoxic drugs combined with molecular targeting drugs for glioma has become the direction of alternative to traditional chemotherapy.