Hepatitis B virus-associated nephritis (HBV-GN), is an immune complex glomerulonephritis caused by chronic hepatitis B virus (HBV) infection. hepatitis B-associated membranous nephropathy was first reported by Combes in 1971, and the diagnostic conditions for HBV-GN in China were recommended by the Beijing symposium in 1989. The rate of HBV infection in China is 9.8%, and there is no reliable data on those who cause kidney damage. The current Western medical treatment of HBV-GN is mainly antiviral and selective immunosuppressive therapy. However, immunosuppressants may contribute to the replication of HBV and aggravate liver damage, and some antiviral drugs are resistant. TCM treatment of HBV-GN has the advantages of regulating the immune system, reducing proteinuria and mitigating liver and kidney damage. 1. Chinese medicine’s understanding of the pathogenesis of HBV-GN. Professor Zhang Qi, a national medical master, believes that the pathogenesis of HBV-GN is spleen deficiency and dampness and toxicity in the liver meridian. Professor Liu Yuning believes that dampness, heat and epidemic toxins are stagnant in the liver and kidney. Prof. Shao Chao-Di believes that the deficiency of positive qi, external dampness and heat, which are embedded in the liver and injected into the kidney, damage the ligaments and veins and become silt for a long time. Li Su-Ling discusses the transmission pattern of HBV-GN and believes that: at the beginning of the disease, damp-heat toxin is embedded in the kidney, blocking the qi mechanism of the target reality, followed by the blood and blood channels are not smoothly formed into silt, damp-heat toxin knots with each other, and long time depletion of qi, resulting in the deficiency of qi, blood, yin and yang. Professor Wang Yao Xian believes that this disease is due to deficiency of the spleen and kidney, dampness and toxicity attack, and positive deficiency and blockage. To sum up the views of all schools of thought, the original deficiency is “deficiency of liver, spleen and kidney”, and the actual symptoms are “damp-heat, depression and siltation”. 2, Chinese medicine treatment (1), identification and treatment: Professor Shao Chao handing from eight types of treatment: (1) damp-heat type with Yin Chen Wu Ling San plus or minus; (2) heat and toxicity type with Rhizoma Rhizoma Di Huang Tang plus or minus; (3) liver depression and spleen deficiency type with Yi Yao San plus or minus; (4) qi stagnation and dampness type with Chai Hu Drainage San combined with Wu Ling San plus or minus; (5) qi deficiency and blood stasis type with Tonifying Zhong Yi Qi Tang combined with blood invigorating products; (6) liver and kidney deficiency type with Qi Ju Di Huang Tang, Mai Wei Di Huang Tang combined with Er Zhi Wan; (7) spleen and kidney yang deficiency type with Zhen Wu For deficiency of the liver and kidney, use Zhen Wu Tang and Real Spleen Drink; for deficiency of the qi and yin, use Liu Wei Di Huang Tang and Sheng Wei San. It is impossible to enumerate them all here because of the inconsistency in the typology and the different medicines used by each school. However, the literature on the treatment of HBV-GN with TCM in the past 10 years was analyzed, and the results are as follows: ① Frequency of TCM evidence: 20 papers were counted, and the frequency of the evidence was ranked as follows: damp-heat internalized evidence (including damp-heat in liver and gallbladder, damp-heat containing toxins, 20 times); liver and kidney yin deficiency evidence (19 times); liver depression and spleen deficiency evidence (16 times); spleen and kidney yang deficiency evidence (including yang deficiency and watery flooding, 8 times); stasis and toxins intertwined evidence (including dampness and siltation blocking ligaments, 6 times); qi stagnation and blood deficiency evidence (including dampness and siltation blocking ligaments, 6 times). (6 times); qi stagnation and blood stasis (including positive deficiency of blood stasis, kidney ligament stasis, qi stagnation and dampness obstruction, 6 times); qi and yin deficiency (4 times); heat and toxin incandescence (3 times). If we simplify the typing, more than half of them are damp-heat internalized evidence, liver-kidney yin deficiency evidence and liver-depressed spleen deficiency evidence. ②Frequency of prescriptions: Liu Wei Di Huang Tang (10 times); Zhen Wu Tang (8 times); Yin Chen Wu Ling San (6 times); Tao Hong Si Wu Tang (6 times); Huang Lian Di Di Tang (4 times); Real Spleen Drink (4 times); Ginseng Qi Di Huang Tang (3 times); Yi Yao San (3 times); Zhi Bai Di Huang Tang (3 times); Chai Hu Dredging Liver San (3 times); Wu Ling San (3 times). Chinese medicine frequency: Poria (25), Astragalus (18), Atractylodes (17), Salvia (17), Radix et Rhizoma (14), Radix et Rhizoma (13), Rhizoma Polygonati (13), Glycyrrhiza glabra (13), Rhizoma Polygonati (12), Radix et Rhizoma Inula (12), Peony bark (11), Radix Zelenia (11), Radix Angelicae Sinensis (10), Cortex Eucommiae (10), Gardenia (10), Radix Codonopsis (10), Radix et Rhizoma Yi (9), Radix Paeoniae Alba (9) (9),Dulcimer (9). (2),Single medicine treatment:Hou Chunsheng found that Astragalus can enhance T-cell function, promote the secretion of interferon, promote the repair of ischemia-reperfusion glomerular damage, and reduce renal histopathological damage.The combination with thymidine can reduce urinary protein and significantly increase serum albumin level in HBV-GN patients. Li Lin et al. treated 32 cases of HBV-GN with heavy use of shamrock, and after treatment, the titer of HBV virus decreased and proteinuria was significantly reduced. Liu Jie et al. used wasabi combined with bitter ginseng to treat 32 cases of HBV-GN, 24h urine protein, BUN and Scr decreased significantly after 12 weeks of medication, and serum albumin increased significantly, and concluded that wasabi combined with bitter ginseng had good effect in treating HBV-GN. 3. Combined Chinese and Western medicine treatment; Wang Hua used morte-macrolide (MMF) at an initial dose of 1.0-1.5g/d, 2/day, which was reduced to 0.75-1.0g/d after 6 months, and took MMF along with morning dose of entecavir (ETV) 0.4mg and prednisone 0.4mg/kg/d, which was gradually reduced after 12 weeks. The dose was gradually reduced after 12 weeks. The dose was also reduced with the main formula of Liver and Kidney Clearance Drink. The efficacy was 70% in 3 months (P<0.05) and 88% after 6 months (P<0.01). 0.01). Meng Xiangang was treated with Ganixin capsule 150mg, 3/day, in severe cases, 150mg of Ganixin by sedation and 1.2g of atomorelin, 1/day. Those with positive HBV replication were given alpha interferon, 3 million units, 1 time/every other day, for 3 months as a course of treatment. The treatment group was treated with Yi Liver and Kidney soup on top of the control group, one dose daily with boiled water for 3 months. Drug composition: Dan Shen 30g, Bitter Ginseng 20g, Atractylodes Macrocephala 25g, Wu Wei Zi 15g, Yam 30g, Astragalus 30g, Niubizi 10g, Poria 15g, Chai Hu 10g, Glycyrrhiza 6g. Add or subtract with evidence. Among the 33 cases in the treatment group, 3 cases were clinically cured, 11 cases were apparently effective, 10 cases were effective, and 2 cases were ineffective, with an overall efficiency of 93.94%, while the efficiency of the control group was 72.73%. 4. Problems and challenges (1). Some TCM literature lacks the basis of nephropathological diagnosis, and some study cases are not necessarily HBV-GN.(2). Most of the healers use drugs based on their own experience, and the clinical research papers lack randomized double-blind controlled studies, much less multicenter clinical studies with large samples. (3). The identification and typing are not uniform among schools, the objectification of symptoms is not consistent, and there is no unified efficacy assessment standard. Therefore, in the future, it is necessary to have a clear diagnosis of renal pathology, develop accepted staging criteria and efficacy assessment criteria, introduce evidence-based medicine methods, and conduct multicenter large-sample randomized double-blind controlled studies to optimize an effective protocol for the treatment of HBV-GN with TCM.