There are many causes of dry eye, and the clinical management of dry eye needs to be tailored to the cause of dry eye. Dry eye is a chronic condition that requires long-term persistent treatment. The most common and convenient method is to insist on saline supplementation or artificial tears. Care should be taken to avoid medications that may reduce tear production, such as clinical blood pressure lowering drugs and atropine-like medications. Care should also be taken in types with immune factor disorders involved to treat the primary cause and symptomatic management of dry eye with immunosuppressants or hormones, such as dry syndrome or lupus erythematosus. It can also be treated clinically with surgery, such as blocking the tear dots with tear plugs or electrocautery to close the tear dots and reduce tear flow. In the case of impaired eyelashes, conjunctival stones require removal of friction factors, and eyelid trauma deformities and incomplete closure require blepharoplasty. Patients with eye fatigue or long-term exposure to computer and cell phone screens need to reduce the intensity of eye use and can wear wet room lenses, silicone eye shields or corneal contact lenses to prolong the residence time of tears on the eye surface. In summary, clinical dry eye treatment is mainly for the cause of the disease, chronic long-term treatment, need to be persistent.