Worry: depressed mood, bitterness, depression, pessimism and despair, a sense of losing all thoughts, light-hearted thoughts, loss of enthusiasm and pleasure in life and work, no interest in everything outside, no joyful feeling; Worry: thoughtfulness, indecisiveness, anxiety, restlessness, or at a loss, sighing, often self-blame and low self-esteem, with a critical, negative and negative attitude to their own present, past and future. The symptoms of physical discomfort such as palpitations, chest tightness, pain, gastrointestinal discomfort, etc.; Dullness: reduced movement, dullness, passivity, slow brain, closed thinking, inattentiveness and memory loss, comprehension is significantly reduced; Laziness: feeling tired and weak for no reason, feeling lazy and incompetent, incompetent, reluctant to move The patient often uses the term “deflated ball” to describe his or her condition; withdrawal: loss of appetite, delicious food is no longer tempting, the patient does not want to eat or eat tasteless, often accompanied by weight loss; sleep disorders, such as Difficulty falling asleep, waking up easily at night, early awakening, lack of sleepiness; hypersexuality, which can occur early in the disease, with men possibly experiencing impotence and women having sensual deficiency.