(According to China Medical Tribune) On March 25, 2010, a professor from the University of Tokyo, Japan, introduced the experience of liver transplantation in Tokyo, Japan, in a special session of the Liver Transplantation Course at the 2010 APASL meeting. Living donor liver transplantation (LDLT) has been widely used in Japan to alleviate the severe shortage of cadaveric liver supply. 443 LDLTs were performed at the University of Tokyo between 1996 and November 2009. Virus-related liver disease (with or without hepatocellular carcinoma) was the most common indication (35%), followed in order by cholestatic liver disease (including primary biliary cirrhosis and primary sclerosing cholangitis, 22%), biliary atresia (20%), and fulminant liver failure (9%). When selecting patients with hepatocellular carcinoma, strict limits were imposed on the condition of the mass (number ≤ 5 and maximum size ≤ 5 cm). Donor livers were selected according to Tokyo criteria (minimum donor liver volume exceeding 35-40% of the recipient’s standard liver volume). Donors were selected from blood relatives within 3 generations. The most commonly used grafts in adults were right liver grafts without a central hepatic vein trunk, followed by left liver with caudate lobe, right liver with a central hepatic vein trunk, and right liver. Donor liver volumes ranged from 31% to 147% of the recipient’s standard liver volume. Overall, the 1-, 3-, and 5-year cumulative survival rates of patients and grafts who underwent liver transplantation were 91%, 87%, and 84%, respectively. Long-term follow-up showed that patients maintained good liver function. All donors returned to normal daily life. We believe that living donor liver transplantation is an effective way to provide patients with good short- and long-term survival. With the severe shortage of cadaveric liver supply, it may be prudent to proceed with living donor liver transplantation.