Acne is a chronic inflammatory skin disease of the follicular sebaceous glands with a prevalence of 70-87% and a psychological and social impact on adolescents that exceeds that of asthma and epilepsy. Treatment options for acne vary widely among clinicians, with some treatments having uncertain efficacy, lacking evidence-based medical evidence to support them, and individual approaches even causing damage to patients. Therefore, it is essential to develop a set of proven guidelines for the treatment of acne to standardize its treatment. Of course, guidelines are not set in stone, and as new evidence-based medical evidence and new drugs are developed, acne treatment guidelines will need to evolve with the times. Moreover, each patient’s condition is different, and it is important to choose the appropriate treatment due to individual differences and different responses to medications. Acne is graded as mild (I): acne only; moderate (II) inflammatory papules; moderate (III): pustules; severe (IV): nodules and cysts. Combined treatment of acne I. Treatment: mainly topical treatment is used. Topical retinoids are preferred, and benzoyl peroxide can be added if necessary. Level II treatment: Topical retinoids are combined with benzoyl peroxide or other topical antibacterial drugs on top of topical retinoids. Oral antibiotics may be added, or physical therapy such as red and blue light irradiation and fruit acid therapy may be added. It can be combined with herbal treatment. Level III treatment: These patients are often treated with combination therapy, in which systematic use of antibiotics is one of the methods of basic treatment, and a sufficient course of treatment is ensured. It is also combined with physical therapy such as red and blue light. Those with poor results can be treated with oral isotretinoin alone and with topical medications to prevent or reduce the development of drug resistance. It can be combined with traditional Chinese medicine treatment. Level IV treatment: Oral isotretinoin is the first-line treatment. Combined level III treatment therapies with herbal medicine. Health education ① Diet: Limit spicy and sweet foods that may trigger or aggravate acne, and eat more vegetables and fruits; ② Daily life: Avoid staying up late, long-term exposure to computers, sun exposure, etc. Pay attention to facial skin cleansing, moisturizing and reducing sebum secretion, and keep bowel movements smooth; ③ Psychological counseling: Acne patients, especially those with severe acne, are more likely to cause anxiety, depression and other psychological problems, so these patients also need Therefore, it is necessary to cooperate with the necessary psychological counseling. Local cleansing should be done with water or suitable facial cleansing products to remove the mixture of excess oil, flakes and bacteria from the skin surface, but should not be overly cleaned. Do not squeeze or scratch lesions such as acne and inflammatory papules with your hands. Daily care Some acne patients have a damaged skin barrier, and long-term oral or topical anti-acne medications such as retinoic acid often aggravate the destruction of the skin barrier and lead to skin sensitivity. Therefore, in addition to medication, physical therapy, and chemical peels, it is sometimes necessary to use efficacious skin care products in combination to maintain and repair the skin barrier function. If accompanied by skin sensitivity, topical soothing and oil-control moisturizing creams should be used, and skin care products with anti-acne effects can be used on local lesions; if the skin shows symptoms such as greasiness and enlarged pores, oil-control moisturizing gel should be mainly used.