Risk factors for the occurrence of depressive disorders 1, genetic factors: the occurrence of depressive disorders is closely related to genetic qualities. Family lineage studies have found that the rate of homozygosity in relatives is much higher than that in the general population. Regarding the mode of inheritance, most scholars now believe that it is polygenic inheritance. 2, gender factors: the proportion of adult women suffering from depressive disorder is higher than that of men, and the ratio is about 2:1. 3, childhood experiences: adverse childhood experiences often constitute an important risk factor for the occurrence of depressive disorder in adulthood. 4, personality factors: personality characteristics with more obvious anxiety, compulsive, impulsive and other traits of individuals prone to depressive disorders. Specific manifestations of excessive suspicion and caution, excessive attention to detail, rules, entries, order or forms, striving for perfection, excessive sense of morality, cautious, over-valuing the effectiveness of work at the expense of fun and interpersonal interactions, excessive adherence to social customs, stereotypes and stubbornness; or to show a continuous and generalized sense of tension and apprehension; or in social situations excessive fear of being accused or rejected by others; or in the style of life have many restrictions; or avoidance of those social or professional activities that involve close interaction with people, etc. 5, psychosocial environment: unfavorable social environment has an important impact on the occurrence of depressive disorders, these unfavorable environments can be summarized as follows: ① Marital status. The risk of depression is significantly higher in individuals who are divorced or separated or widowed than in those with good marital status, with men being more prominent; ② Economic status. Major members of low-income families are prone to depression; ③ Life events: major sudden or life events lasting more than 2 to 3 months pose an important influence on the occurrence of depression in individuals. Major life events such as the death of a loved one or the loss of a relationship can be a direct factor leading to depressive disorder. 6, somatic factors: physical diseases, especially chronic central nervous system diseases or other chronic physical diseases can be an important risk factor for the occurrence of depressive disorders. Such as malignant tumors, hypothyroidism, Parkinson’s disease, epilepsy, etc. 7, psychoactive substance abuse and dependence: including opiates, central stimulants, hallucinogens, alcohol, sedative-hypnotic drugs, etc. 8, drug factors: certain drugs can cause depressive disorders during treatment, including certain antipsychotic drugs (such as chlorpromazine), antiepileptic drugs (such as sodium valproate, phenytoin sodium, etc.), anti-tuberculosis drugs (such as isoniazid), certain antihypertensive drugs (such as colistin, reserpine, etc.), anti-Parkinson’s disease drugs (such as levodopa), glucocorticoids (such as prednisone), etc. It is important to note that risk factors work together in many cases; for example, in addition to irresistible external factors that influence marital status, individual personality characteristics also tend to influence marital relationships. When examining risk factors for depressive disorders, the problems present in particular individuals should be analyzed specifically. Evidence suggests that the combined effect of factors such as positive family history, life events, and personality defects can significantly increase an individual’s risk of developing depressive disorders.