The pain caused by osteoporosis is mainly characterized by the following: 1. The site of onset is located in the lower back, although patients are generally not able to locate the specific location of the pain, and as the disease progresses, the pain may spread to the extremities, for example, it may develop in the upper arm, wrist, hip, knee, etc. 2. In most cases, the pain is only severe when a pathological fracture occurs. 3. The pain occurs mainly in the early morning, but may also be felt during sudden activity after sitting or standing for a period of time. 4. There are triggering factors associated with this pain, such as increased pain after overexertion, heavy weight-bearing, or cold.