Due to its high incidence, complex etiology, long course and difficulty in treatment, intractable functional constipation has become one of the important factors affecting the quality of life of modern people. 1, blood deficiency and blood stasis is the key pathogen of intractable functional constipation Constipation is a gradual process. In the early stage of the disease, it is mostly caused by heat and dryness or emotional and mental disorders that lead to qi stagnation, but patients with this disease mostly have a long history of constipation, consuming qi and injuring blood over time, which is more obvious in people who are sick, postpartum and elderly and weak. Most of the patients take bitter-cold laxatives or stimulant laxatives for a long time for the sake of momentary laxation. Bitter-cold agents taken for a long time damage the spleen and stomach, damage stomach qi, no thought of eating and drinking, no material in the grain, unable to form effective defecation stimulation; spleen qi is damaged, transportation and transformation are out of order, the large intestine conduction is not normal, the dregs stop inside, forming constipation; stimulant laxatives mostly contain anthraquinones, long-term use damages the intestinal nervous system, and can lead to colon blackening, causing In order to maintain the laxative effect, the dose of medicine is increasing, but the effect is getting worse, forming a vicious circle. Professor Li believes that patients with a long history of this disease, blood stasis pathological manifestations should not be ignored, and patients mostly have purple dull tongue, although there are no obvious blood stasis symptoms such as petechiae and petechiae, but the use of blood products to promote blood circulation and resolve blood stasis received miraculous results. Constipation patients have slowed down intestinal peristalsis, and feces accumulates in the intestine for too long, compressing the intestinal wall and blocking the intestinal ligaments, making the blood flow in the intestinal wall sluggish and astringent, which is in line with the theory of “prolonged illness with more stasis” and “prolonged illness into the ligaments”. In addition, blood deficiency is also an important cause of blood stasis, as blood deficiency and fluid deficiency, lack of yin and fluid, and loss of intestinal moistening. The result can lead to dry and hard stools, blocking the blood channels of the intestinal wall and aggravating the stasis of blood in the intestinal wall, and also due to the deficiency of blood and yin and fluid, resulting in emptying of the pulse channels and poor blood flow, making the stasis of blood in the intestinal wall even worse. The clinical manifestations of this disease are constipation, difficult discharge, few bowel movements, one bowel movement in 4-5 days, or even one row in 10 days, lack of color, dizziness, palpitations, weakness and little movement, pale lips, light or purple dull tongue, and thin and astringent pulse. Young female patients have prolonged menstruation or low menstrual flow, or dysmenorrhea. 2. Commonly used drugs: Angelica sinensis, Radix et Rhizoma ginseng, Rhizoma Chuanxiong, Radix paeoniae, Peach kernel, Radix heshouwu, Atractylodes macrocephala. Among them, Radix Angelicae Sinensis tonifies blood, invigorates blood, laxative, and laxative. The “Materia Medica Preparation” says that Radix Angelicae Sinensis “can pass blood stagnation, blood deficiency can be tonified, blood exhaustion can be moistened, blood disorder can be soothed”, which is indispensable for the treatment of stubborn constipation. often forced, are blood deficiency blood astringency, add angelica body three points.” Chuanxiong, red peony, Sheng Dihuang nourishes blood and invigorates blood, and also Sheng Dihuang can produce fluid and moisten dryness and open the bowels; Peach kernel invigorates blood and dispels blood stasis and moistens dryness and smooths the bowels; He Shou Wu moistens the bowels and opens the bowels, and also replenishes the kidneys and fills the essence to replenish the innate essence and help the kidneys to divide the bowels; the heavy use of Atractylodes can both open the bowels and strengthen the spleen to help the source of Qi and blood biochemistry, nourishing blood and replenishing deficiency. The earth is strong, the clear qi is good at ascending, and the essence is served; the turbid qi is good at descending, and the dregs descend”. 3, typical case Patient, female, 48 years old, company employee. The patient has had constipation for more than 40 years. Now she has dry and hard stools, granular in shape, with difficulty in discharge, one line of stool in 4-5 d, unpleasant after stool, feeling dizzy and dizzy after stool, occasional palpitations, dull stasis on the tongue, petechiae on the tip of the tongue, thin white fur, sunken and thin pulse. He has taken oral laxative drugs for weight loss for more than 10 years, but is constipated when he stops taking them. The evidence is: Blood deficiency and stagnation, loss of intestinal moistening. The treatment is to nourish Blood, invigorate Blood and promote laxity. Prescription: Radix Angelicae Sinensis 15g, Rhizoma Dioscoreae 15g, Rhizoma Ligustici Chuanxiong 10g, Radix Paeoniae Alba 10g, Rhizoma Peach kernel 25g, Rhizoma Polygonati 20g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Almond 10g, Rhizoma Citrus Auranti 15g, Rhizoma Cistanches 15g, Rhizoma Guadua 10g, Radix Glycyrrhiza Uralensis 9g. After taking 14 doses, he reported that he could pass stool once, and the effort to pass stool was significantly reduced, and he felt smooth when passing stool, without dizziness and palpitations. The previous prescription was given with the removal of Citrus aurantium and almonds and the addition of safflower 10g, followed by 14 doses, and the stool was passed once in 1 to 2 d. All remaining symptoms were removed and the pulse improved. Advised to pay attention to diet, stopped taking the medicine for more than 2 months without recurrence. 4, summary Functional constipation needs to exclude the intestinal tract itself and systemic organic etiology, appropriate physical and chemical examination is indispensable, rectal examination can find the normal function of the anus and pelvic floor muscles and defecation coordination, to exclude the existence of outlet obstructive constipation, if necessary, fecal imaging and fiber colonoscopy to exclude pelvic floor dysfunction or intestinal organic lesions. In the treatment of constipation from blood, Prof. Li emphasizes that “blood and fluid have the same source”, and if blood is strong, fluid will be sufficient, intestine will be moistened, transmission will be smooth, and constipation will be removed. If blood is deficient, there is no source of fluid biochemically, the intestines are not moistened, and dryness and knots arise, thus making constipation difficult. Blood deficiency is also an important cause of blood stasis. Blood stasis does not necessarily mean stagnation of blood, but also slow and astringent blood flow is a state of blood stasis, that is, “blood flow is out of proportion” as stated in “Treatise on the Origin of Diseases – Loss of Blood Stasis in the Bed”. Slow blood flow in the intestinal tract prevents blood from nourishing the intestinal wall, resulting in impaired smooth muscle dynamics in the intestinal tract, slow transmission, weakened propulsive movement, and stagnation of intestinal contents, resulting in constipation. In view of this, Prof. Li’s treatment of constipation is never a delusional attack, as stated in “The Complete Book of Ancient and Modern Medicine – Constipation Waiting”: “If you take Fast medicine, fluid away, qi and blood consumption, although temporary pass, and that is secret carry on.” Constipation causes a variety of, from the blood theory of constipation need to identify accurate, there is the evidence with the medicine, must correspond to the prescription, can not be generalized, see the constipation that from the blood theory of treatment will not be effective.