Gestational remnants and trophoblastic disease can be differentiated on the basis of β-HCG levels. Gestational tissue remnants have low β-HCG levels and trophoblastic diseases have high β-HCG levels. Incomplete abortion with retained gestational tissue is the most common condition to be differentiated from trophoblastic disease, with lesions confined to the uterine cavity and localized endothelium, focal dilatation of subendothelial blood vessels, and low blood β-HCG levels. Trophoblastic tumors in trophoblastic disease may present as solid lesions resembling fibroids and can be differentiated from gestational residual pathology on the basis of elevated β-HCG levels. Trophoblastic diseases of pregnancy encompass a spectrum of trophoblastic lesions whose biological behavior is characterized by potential invasion of surrounding tissues and distant metastasis. For example, malignant aggressive hyperemesis gravidarum, choriocarcinoma, placental trophoblastic tumors and epithelioid trophoblastic tumors, collectively known as gestational trophoblastic tumors, can develop distant metastasis, which can lead to death if not diagnosed and treated in time. Patients are advised to go to professional hospitals for identification and under the guidance of doctors for appropriate examination and treatment.