Sperm are the messengers of fertility and the testes produce sperm. Everything that affects the testicles can affect fertility. For example, inflammation, injury, infection of the testes and epididymis, varicocele, prostate disease, erectile dysfunction (commonly known as impotence), retrograde ejaculation, genetic abnormalities, endocrine disorders, immune factors, etc. The public is more concerned with lifestyle related issues. In fact, male infertility, sometimes it may help to be more careful in life itself. For example, alcoholism is very damaging to sperm, so the deformity rate of “cave children” and “honeymoon children” is higher. It is good to have tight pants, sauna, house renovation, and meat with too much hormone content are all factors that lead to infertility. In addition, the pressure of competition in modern society has increased, and mental tension and anxiety can easily affect the endocrine system of men, resulting in reduced fertility. Liu Wanpeng, Department of Reproductive Medicine, The First Hospital of Bin Medical University A clear diagnosis is very important for male infertility patients. The purpose of diagnosis is to determine fertility and find possible causes, and to lay the foundation for subsequent treatment. However, the exact cause of most infertility is still unclear, and only about 1/4 of them can really find the cause of infertility. In recent years, using cytogenetics, immunology, microbiology, reproductive endocrinology, imaging, and genetic testing of molecular biology, the understanding of the cause and pathogenesis of male infertility has become more comprehensive and in-depth, and some causes of male infertility have been explored.