Cervical cancer is one of the most common gynecological cancers, and its incidence and death rate remain high, posing a serious threat to women’s life and health. Currently, the internationally recognized causative factor of cervical cancer is the persistent infection of high-risk human papillomavirus (HPV), and HPV vaccine can block the persistent infection of high-risk HPV, which can effectively prevent the occurrence of cervical cancer. Currently, there are three types of cervical cancer vaccines approved by China Drug Administration in the market. They are as follows: bivalent vaccine: HPV subtypes 16 and 18 can be prevented, mainly for cervical cancer, and the recommended vaccination age is 9 to 25 years old women. The bivalent vaccine can prevent 70% of cervical cancers, and a three-dose vaccination strategy is used (one dose each in the 0th, 1st and 6th months). Quadrivalent vaccine: HPV subtypes 16, 18, 6 and 11 can be prevented. In addition to cervical cancer, HPV can also prevent penile cancer, anal cancer, genital warts and other diseases. The quadrivalent vaccine can prevent 70% of cervical cancer and vulvar warts with a three-dose vaccination strategy (one dose each at 0, 2, and 6 months). Nine-valent vaccine: The most HPV subtypes can be prevented, including 16, 18, 6, 11, 31, 33, 45, 52, 58, which can prevent more than 90% of cervical cancer, and the recommended vaccination age for women is between 16 and 26. It can prevent more than 90% of cervical cancer, vulvar cancer, anal cancer, genital warts and precancerous or atypical lesions, using a three-dose vaccination strategy (one dose each at 0, 2 and 6 months). All three vaccines are 9-valent > quadrivalent > bivalent in terms of effectiveness and price. Regardless of which cervical cancer vaccine is used, its safety and immunity have been proven in trials, as the risk of HPV exposure increases with age, especially after sexual intercourse. Therefore, it is recommended that women who are sexually active should be vaccinated as early as possible, regardless of which vaccine is available. Other women of age can choose the appropriate HPV vaccine for their age and economic conditions. References: [1] Yang M. How much is known about cervical cancer preventive vaccine[J]. Science of Health. 2020,23(7): 92[2] Hu Guiqiong. Is the cervical cancer vaccine important? Should we get it or not? [J]. Nutritional Health Care Guide.2019,43:63[3]Wu BJ,Yang ZJ.Research progress of HPV and its related vaccines[J]. Medical review.2018,24(4): 662-671[4]Li Zhengxing,Sheng YH. A survey of nine-valent human papillomavirus vaccination among female students in a higher education institution in Yunnan[J]. Journal of practical medicine and technology. 2021,28(7): 847-850