Some people equate thyroid nodules with calcification with thyroid cancer and believe that nodules with calcification must be malignant, but this is not true. Although it is true that the incidence of calcification in malignant nodules is significantly higher than that in benign nodules, thyroid nodules with calcification can be both malignant and benign, and cannot be generalized. Of course, the shape, size, and distribution of calcification foci are of great importance in determining the benignity and malignancy of nodules. Calcifications can be classified as microcalcifications, coarse calcifications, marginal calcifications, and calcified spots according to their characteristics. Microcalcifications are mostly characteristic of thyroid cancer, while coarse calcifications, marginal calcifications and calcified plaques are usually caused by local “malnutrition” of the thyroid gland, such as inflammation. Calcifications in benign nodules are mostly coarse, small patchy or arc-shaped, with a more concentrated distribution, while calcifications in malignant nodules are mostly sand-like microcalcifications with a scattered or limited distribution. For calcifications of other nature, it is important to ask an experienced doctor to diagnose them and not to scare yourself.