The application of Pingyangmycin in the treatment of hemangioma I. Concentration, dose and course of treatment Select the appropriate concentration and dose according to the age of the child, the location of the lesion, the size and type of hemangioma. Generally speaking, low concentration and small dose should be used for young children, superficial lesions and those occurring in the eyelids and perineum. If the hemangioma is large, the treatment should be divided into two doses, and if the hemangioma does not heal in one dose, it should be injected once every two weeks, and two to five doses should be used as a course of treatment. The dose of each injection should not exceed 8 mg, and the total dose of the drug should not exceed 40 mg. The lesion should be routinely disinfected, the required Pingyangmycin solution should be extracted, and the needle should be inserted with a No. 5 needle 1~2 mm from the edge of the hemangioma, and the drug should be injected in a radial manner in different directions, so that the drug can be evenly distributed in the tumor, and it is better if the hemangioma is full or the surface is pale. After the injection, local pressure is applied to stop the bleeding. The main component is bleomycin A5, which has an inhibitory effect on vascular endothelial cells. Since simple and mixed hemangiomas have the characteristics of infantile embryonic vascular endothelium, intra-tumor injection can inhibit the proliferation of vascular endothelial cells and make the hemangioma regress. In spongiform hemangioma, there are large and irregular lumens similar to venous sinus in the lesion tissue, and the luminal wall is monolayer endothelial cells, so the local drug concentration is high after injection, and the endothelium is destroyed and the hemangioma degenerates. The incidence of adverse reactions and prevention of complications was 17.5%, including fever. The occurrence of adverse reactions and complications in some children is related to the young age of the children, high drug concentration, high dose and treatment site. In the treatment, by adjusting the concentration and dose of drugs, the occurrence of such phenomena can be reduced. V. Treatment method Take Pingyangmycin 1mg-8mg and Dexamethasone 1mg-5mg at one time, dilute them with 2% lidocaine 1ml-3ml, disinfect the lesion area of the tumor routinely, apply pressure 0.5cm outside the tumor to block the blood flow, stab the tumor with a No.5 injection needle, try to draw out the blood in the tumor, and then inject the drug, according to the size of the tumor, the treatment can be done at a stabbing point in a After the injection, the skin or mucous membrane on the surface of the tumor becomes white and the local pressure is continued for 2-3 minutes to prolong the action time of the drug in the tumor. Caution 1: The concentration of the drug solution is generally 0.1% for hemangioma and 0.2% for vascular malformation. 2:The treatment of hemangioma can add the appropriate amount of dimethoate, which also has the effect of inhibiting angiogenesis. However, in order to prevent postoperative fever, it is sometimes possible to inject an appropriate amount of demi into the body. 3:The injection should be done from the periphery of the tumor 0.5cm, and the injection should be done in multiple points in the area, not from the middle of the tumor and not in a full amount, in order to prevent the leakage of the drug and the collapse of the tumor. 4: Injections for vascular malformations should be done only after blood is drawn back. 5:The amount of one injection should not exceed 8mg.