The duration of HPV18 positivity in the body is related to the degree of the disease. Most patients can clear the virus from their bodies in time after active treatment and the HPV virus can be turned negative. HPV18 infection is a high-risk type and patients have a higher chance of developing cervical intraepithelial neoplasia or cervical cancer, but only persistent infection will cause cervical lesions, so there is no need to worry too much. Patients infected with HPV type 18 should undergo cervical TCT and colposcopy in time to determine whether there is cervical lesion. If abnormalities exist, cervical treatment or cervical conization should be performed promptly and further treated according to the postoperative pathology results. If the patient has no special clinical symptoms and the pathology is not abnormal then the application of drugs such as interferon is optional and the patient can be reviewed after 3-6 months. Through the above-mentioned standardized treatment, the virus in most patients can be turned negative and there will be no major impact on the body. In addition, patients need to strengthen exercise, such as running, swimming and other ways to increase immunity, help the virus to turn negative, and thus facilitate the recovery of the disease.