There are two major types of medications for acne treatment: oral and topical. For some patients with poor results, red and blue light, fruit acids, photorejuvenation and photodynamic therapy are also available and need to be chosen in conjunction with specific conditions. In case of simple white pimples without surrounding redness, adapalene gel is preferred, or when not available, 0.1% retinoic acid ointment. For those with red papules, a combination of oral medications is recommended. The first-line oral medication for acne treatment is Tylenol, which regulates cellular keratinization and is effective, but also causes dryness of the mouth and lips and mild dermatitis. If tolerated, it is recommended to be used for more than 3 months and has a better effect on preventing acne recurrence. For inflammatory papules, topical antibiotics (fusidic acid ointment) or herbs with anti-inflammatory effects (turmeric antizole rub) or mediation of keratinization (peroxynivalenol gel) are recommended. For severe acne that does not work well with oral and topical applications alone, a combination of phototherapy, such as red and blue light and ALA photodynamic therapy, can be used. For patients with more acne marks, auxiliary treatments such as fruit acids and azelaic acid can also be used. Most acne patients with greasy sebum can take oral vitamin B6 and other medications to improve oil secretion. Acne has a complex etiology and is prone to recurrence. There are more drugs available, and a reasonable choice according to the specific condition is the key to treatment.