I. The introduction of the concept of clustering intervention is beneficial to the development of infectious disease critical care medicine department Critical care medicine is an emerging discipline of modern medicine and one of the important symbols of medical progress. In order to improve the technical level of providing standardized and high-quality life support for critically ill patients in the specialty of infectious diseases (infectious diseases) and enhance the comprehensive treatment capability and overall medical strength of the hospital, we introduced the concept of clustering intervention into the specialty of infectious diseases (infectious diseases) and strengthened the construction of intensive care treatment unit (ICU). We also introduced the concept of cluster intervention in the clinical practice of the Department of Critical Care Medicine, especially in the treatment of liver failure, which has important practical significance and broad prospects for the construction and improvement of the critical care system for infectious diseases. Bundles of Care is also known as bundles of treatment or bundles of care. It is a series of treatments and measures from clinical practice, based on evidence-based medicine, grouped into systematic treatment steps to deal with a difficult clinical disease, breaking through the original single treatment technology model of infectious disease specialties to maximize the effect of integrated treatment. We provide patients with the best possible treatment process and medical services, and promote the implementation of standardized treatment plans in the clinic. Since the establishment of the department, we have transformed the previous narrow thinking of diagnosis and treatment and taken the lead in applying the concept of Bundles of Care in the treatment strategy of liver failure, setting active treatment goals for patients with complex and variable liver failure according to the different pathological mechanisms and timing of disease onset and development. We have designed a comprehensive treatment plan around the treatment goals, and at the same time have a clear time, goal and sequential implementation process, put forward the strategy of liver failure clustering, trying to manage patients with the concept of critical care medicine, more than a thousand cases of liver failure patients admitted and treated, after unremitting exploration to obtain good clinical results, the success rate of liver failure patients rescued reached 72%, the death rate reduced by 30%. Our department has become a platform for advanced resuscitation, centralized treatment and monitoring of critically ill patients, and a special department and scientific research base for the admission of critically ill liver diseases. Second, the application of the concept of centralized intervention in the clinical treatment of liver failure Liver failure is mostly manifested as multi-organ failure with liver failure as the main cause, which is one of the most serious types of clinical diseases and can often lead to liver coma, serious infection, bleeding, multi-organ failure and other complications, and the condition is so dangerous that the current morbidity and mortality rate is over 70%. In the past, patients with liver failure were not included in the scope of admission to the critical care unit, so there was a lack of active, standardized, targeted consideration and all-round thinking in the treatment of patients with liver failure, resulting in a high death rate of patients with liver failure. In this regard, according to the requirements of discipline construction, we have tried to develop diagnostic thinking, change the treatment mode, optimize the process management, emphasize respect for life, cultivate complex talents, build an excellent team, explore and summarize continuously in clinical practice, and make efforts to improve. In the clinical treatment of patients with liver failure, we mainly apply the concept of cluster intervention in clinical practice through four levels: (a) According to the requirements of critical care medicine, we have formulated the text of SOP for the diagnosis and treatment of critical infectious diseases, reconstructed ward management protocols, standardized the process of patient management and disinfection and isolation, and systematically strengthened infection prevention and control. (2) Based on the high standard of medical technology, we have advanced and comprehensive medical equipment, monitoring means and treatment capability. (iii) Through the way of upgrading the education of medical and nursing staff through directed further training, graduate school and doctoral examinations, we have cultivated a composite skill team that can master various professional directions such as clinical anti-infection, blood purification (artificial liver) nephrology, cardiovascular science, infectious hepatology, clinical nutrition, etc., changing the single talent structure that used to have only specialized knowledge of infectious diseases. (d) During the long-term cooperative work, our department has gathered the best human and material advantages of the hospital, and also established an interconnection platform with many famous hospitals in Shanghai and even in foreign provinces and cities, forming a network of wise advisors with the participation of experts from various departments, which provides a powerful support system to improve the medical level and response ability of our department. Now we have the ability to independently complete CPR, artificial airway establishment and management, mechanical ventilation techniques, deep vein placement techniques, hemodynamic monitoring, continuous blood purification and artificial liver techniques, and enteral over-the-counter nutrition support. Better master the theory and skills of monitoring and supporting vital organ function in critically ill patients, and also have the ability to respond quickly to abnormal information about organ function and life, including: shock, respiratory failure, cardiac insufficiency, severe cardiac arrhythmia, acute renal insufficiency, central nervous system dysfunction, severe liver dysfunction, gastrointestinal dysfunction and gastrointestinal hemorrhage, post-liver transplantation monitoring, sedation and analgesia, severe infection, and multi-organ dysfunction. It provides a more accurate, convenient, faster and safer medical service platform for patients. The prospect of the development of the concept of cluster intervention in the Department of Infectious Diseases and Critical Care Medicine At the beginning of the establishment of the department, we put forward the idea of providing a systematic, specialized and cluster treatment platform for patients with liver failure and liver disease related problems, and through eight years of clinical practice, our department is working hard toward this goal, and the prospect is broad. But in general, it is still in the exploration stage. In order to further improve the success rate of resuscitation of liver failure patients, we need to continuously absorb the advanced concepts and treatment methods of critical care and other disciplines in the process of clinical practice against the requirements of evidence-based medicine, and provide evidence-based medicine in multiple ways by scientifically designing and strictly executing clinical experimental protocols and making objective and systematic evaluation of clinical outcomes against the two different clinical practice methods of traditional and clustering. To confirm the validity of clinical outcomes by scientifically designed and rigorously implemented clinical trial protocols, objective and systematic evaluation of clinical outcomes against two different clinical practice methods, traditional and cluster, and multiple ways to provide evidence-based medicine. In order to develop and optimize the clustered treatment strategy for patients with liver failure, it is necessary to stratify the diagnosis and treatment of different patients through scientific quantitative assessment methods, from which the best evidence that can be followed, objective and generated through clinical scientific research can be extracted, and gradually form a scientific, standardized and operable professional treatment model, and become a way to improve the level of physicians’ resuscitation treatment for patients with critical liver failure and to guide clinicians in the treatment of It will also become the entry point and grasp for improving the level of physicians’ resuscitation treatment for patients with critical liver failure and guiding clinicians’ treatment process for critical patients. Under such a guiding ideology, we are going to introduce advanced multidisciplinary treatment ideas and measures, and will design different clinical treatment plans according to the different stages of disease development, different etiological mechanisms, and different prognostic judgments for patients with liver failure. For example, we have designed “Evaluation of the efficacy of sodium phosphocreatine in the treatment of slow plus acute liver failure” and “Safety and efficacy of parenteral total nutrition in the treatment of liver failure patients” to promote cell repair and regeneration. In terms of targeting immune damage, we organized “Effect of Ustatin on Coagulation Function in Patients with Acute Liver Failure” and “A Multicenter, Randomized, Controlled Clinical Study on the Effect of Blood Bicarbonate Injection on Coagulation Function in Patients with Slow Plus Acute Liver Failure”. A randomized, single-blind, parallel-controlled clinical study to evaluate the efficacy and safety of different doses of Arbose (ornithine meninate injection) in the treatment of patients with severe hepatitis with or without renal insufficiency complicated by hepatic encephalopathy”, Terlipressin to prevent hepatorenal syndrome, and Tolvaptan to correct endoenvironmental disturbances to eliminate ascites, etc. were designed to improve the efficacy and safety. The different topics of clinical optimization treatment evaluation have developed and enriched the ideas and means of clinical treatment for patients with liver failure, and the already developed software for registration and follow-up of liver failure diagnosis and treatment has been continuously improved to achieve the purpose of correct and scientific systematic evaluation of clinical outcomes for patients admitted and treated, so that the model of centralized treatment can play a greater role in the field of critical care of infectious diseases.