The main similarities and differences between acute and subacute infective endocarditis: 1. Acute infective endocarditis is mainly caused by Staphylococcus aureus, while subacute infective endocarditis is mainly caused by Streptococcus griseus, which is the most common cause. 2. The pathogenesis of acute is not particularly clear, mainly involving the heart valves, especially the aortic valve is the most commonly involved, while subacute often occurs on the basis of organic heart disease and develops into heart valve lesions. 3, acute infective endocarditis can be life-threatening if untreated within 4 weeks, while subacute generally ≥ 6 months when heart failure is aggravated, the common denominator is mainly clinical symptoms, performance and signs are the same, mainly manifested as fever, heart murmurs and peripheral signs, prone to arterial embolism and heart failure is also a more serious In terms of diagnosis, positive blood culture is of great value for diagnosis, and treatment mainly includes medication and surgical treatment.