Syphilis infection during pregnancy or gestation Generally speaking, during the first 4 months of pregnancy, it may be that the trophoblastic layer of the placenta has a barrier and isolation effect, and the syphilis spirochetes are not easily affected by passing through the placenta, while after 4 months of pregnancy, the trophoblastic layer of the placenta atrophies, at which time the syphilis spirochetes can easily pass through the placenta and enter the fetus. Therefore, untreated syphilis in women who are already pregnant will have serious consequences. If you are pregnant with syphilis (or have syphilis after pregnancy), in the early stages of pregnancy, because of the large number of syphilis spirochetes in the mother’s body, the infection is strong, so 50% of the fetus will die before full term; or although it is a full term baby, but after delivery is a stillborn baby, we call stillbirth or stillbirth; and the other 50% was born, but the end is very bad, because they will be put on the earth as soon as they come to earth The other 50% are born but end up in a bad way, because they will be labeled as “syphilis babies” as soon as they arrive on earth. Another situation that is easily overlooked is that of pregnant women with early latent syphilis. They have been infected with syphilis for less than 2 years and may not have any clinical manifestations at the time of pregnancy, so they think they have recovered or never had the disease at all and are ready to have a baby. In fact, during this period, the blood in the pregnant woman is also infectious, and the result of the pregnancy is that 20% of births are stillborn, 40% of babies are infected with syphilis, and only 20% of babies are likely to be normal. What about pregnant women with late-stage syphilis? Generally speaking, the longer the stage of the disease, the less contagious it is. Of course, this is not to say that it is not contagious; any woman with more than 2 years of disease can still transmit the disease to her fetus if she becomes pregnant. About 20% of babies born to pregnant women with advanced syphilis are stillborn or stillborn and 10% are syphilitic, but 70% may be normal babies. The question of how to handle a pregnancy with syphilis is more complicated. In a family where both spouses have had syphilis or a history of unclean sex before or after marriage, the safest way to get pregnant before having a child is to go to a regular hospital dermatology and venereology department for a comprehensive examination to rule out syphilis or to confirm that the syphilis they have had has been cured and that they are not suffering from other STDs. If a woman who has had or has recently had an unclean sexual life is pregnant, she must undergo a serological screening test for syphilis within the first 3 months, as well as a confirmatory test, and if the results of both tests are negative, the test will be repeated after 4 weeks, still negative and without clinical symptoms, without treatment, but if one of the tests is positive, she must receive treatment. After 6 months of pregnancy, the above test must be done again. If the first 3 months of pregnancy and the last 3 months of pregnancy are both negative, treatment can be dispensed with; if the first 3 months of pregnancy are positive and have been treated, the last 3 months of pregnancy still need to be treated once more, and if the last 3 months of pregnancy are still positive, then it goes without saying that treatment should be continued. If a pregnant woman still has a history of unclean sex in the second trimester and suspects that the other party is a syphilis patient, treatment must be given in the last trimester to prevent future problems. All babies born to pregnant women with the above conditions must be tested for syphilis serology at birth, in the first month after birth, every 3 months during the first year of life, and every 6 months from 1 to 2 years of age, and only if they are negative. If the test is positive during the follow-up, the infant should be treated promptly. If the pregnant woman is unable to receive regular treatment, or if the infant appears to be healthy but cannot be guaranteed close serologic follow-up within 2 years, treatment for syphilis should be given immediately at birth.