Depression can cause chronic pain. The incidence of its accompanying pain is as high as 40-60%, with headache, back pain, chest pain, abdominal pain, joint pain, and extremity pain being the most common. It has been suggested that the majority of non-organic chronic pain is due to depressed mood. These patients tend to be less depressed, but the somatic pain persists. Pain due to depression is usually most common in the early stages with headache. The degree and nature of this pain varies with the patient’s mood and may later develop into pain in other areas, such as back pain, abdominal pain, and low back pain. Most of the pains that appear due to depression tend to be long-lasting and recurrent, and although the degree is not particularly serious, the conventional treatment is not effective, causing the patient to suffer, and instead, he or she believes that he or she is depressed because the pain does not get better all the time. Studies have shown that depressed patients who suffer from physical pain delay going to the doctor for an average of 11 months and are diagnosed with depression after an average of five visits. 72% of patients do not recognize that their chronic physical symptoms are closely related to depression until they are diagnosed with depression. Chronic pain and depression can co-exist, mutually precipitate or exacerbate each other, adding a mental dimension to the patient’s somatic pain and negatively impacting their quality of life; treating the somatic pain that accompanies depression is critical to the overall treatment of depression. Early diagnosis and treatment of depression, as well as treatment of both the emotional symptoms of depression and painful somatic symptoms, are necessary to achieve clinical cure of depression. Current antidepressants with good efficacy for pain are commonly used as highly selective 5-HT or/and dopamine, norepinephrine (NE) in uptake inhibitors, etc.